Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23292 | Target Info | |||
| Target Name | N-acetylgalactosamine 6 sulfatase (GALNS) | ||||
| Synonyms | N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfatase; Galactose-6-sulfate sulfatase; GalNAc6S sulfatase; GalN6S; Chondroitinsulfatase; Chondroitinase | ||||
| Target Type | Successful Target | ||||
| Gene Name | GALNS | ||||
| Biochemical Class | Sulfuric ester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 3,3-Dihydroxy l-alanine | Ligand Info | |||||
| Structure Description | The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc | PDB:4FDJ | ||||
| Method | X-ray diffraction | Resolution | 2.81 Å | Mutation | No | [1] |
| PDB Sequence |
PQPPNILLLL
37 MDDMGWGDLG47 VYGEPSRETP57 NLDRMAAEGL67 LFPNFYSANP77 LSPSRAALLT 88 GRLPIRNGFY98 TTNAHARNAY108 TPQEIVGGIP118 DSEQLLPELL128 KKAGYVSKIV 138 GKWHLGHRPQ148 FHPLKHGFDE158 WFGSPNCHFG168 PYDNKARPNI178 PVYRDWEMVG 188 RYYEEFPINL198 KTGEANLTQI208 YLQEALDFIK218 RQARHHPFFL228 YWAVDATHAP 238 VYASKPFLGT248 SQRGRYGDAV258 REIDDSIGKI268 LELLQDLHVA278 DNTFVFFTSD 288 NGAALISAPE298 QGGSNGPFLC308 GKQTTFEGGM318 REPALAWWPG328 HVTAGQVSHQ 338 LGSIMDLFTT348 SLALAGLTPP358 SDRAIDGLNL368 LPTLLQGRLM378 DRPIFYYRGD 388 TLMAATLGQH398 KAHFWTWTNS408 WENFRQGIDF418 CPGQNVSGVT428 THNLEDHTKL 438 PLIFHLGRDP448 GERFPLSFAS458 AEYQEALSRI468 TSVVQQHQEA478 LVPAQPQLNV 488 CNWAVMNWAP498 PGCEKLGKCL508 TPPESIPKKC518 LW
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| Ligand Name: N-Acetyl-beta-D-galactosamine | Ligand Info | |||||
| Structure Description | The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc | PDB:4FDJ | ||||
| Method | X-ray diffraction | Resolution | 2.81 Å | Mutation | No | [1] |
| PDB Sequence |
PQPPNILLLL
37 MDDMGWGDLG47 VYGEPSRETP57 NLDRMAAEGL67 LFPNFYSANP77 LSPSRAALLT 88 GRLPIRNGFY98 TTNAHARNAY108 TPQEIVGGIP118 DSEQLLPELL128 KKAGYVSKIV 138 GKWHLGHRPQ148 FHPLKHGFDE158 WFGSPNCHFG168 PYDNKARPNI178 PVYRDWEMVG 188 RYYEEFPINL198 KTGEANLTQI208 YLQEALDFIK218 RQARHHPFFL228 YWAVDATHAP 238 VYASKPFLGT248 SQRGRYGDAV258 REIDDSIGKI268 LELLQDLHVA278 DNTFVFFTSD 288 NGAALISAPE298 QGGSNGPFLC308 GKQTTFEGGM318 REPALAWWPG328 HVTAGQVSHQ 338 LGSIMDLFTT348 SLALAGLTPP358 SDRAIDGLNL368 LPTLLQGRLM378 DRPIFYYRGD 388 TLMAATLGQH398 KAHFWTWTNS408 WENFRQGIDF418 CPGQNVSGVT428 THNLEDHTKL 438 PLIFHLGRDP448 GERFPLSFAS458 AEYQEALSRI468 TSVVQQHQEA478 LVPAQPQLNV 488 CNWAVMNWAP498 PGCEKLGKCL508 TPPESIPKKC518 LW
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The structure of human GALNS reveals the molecular basis for mucopolysaccharidosis IV A. J Mol Biol. 2012 Nov 9;423(5):736-51. | ||||
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