Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T22032 Target Info
Target Name Parathyroid hormone receptor (PTH2R)
Synonyms PTHR2; PTH2R; PTH2 receptor
Target Type Clinical trial Target
Gene Name PTH2R
Biochemical Class GPCR secretin
UniProt ID
PTH2R_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and G protein PDB:7F16
Method Electron microscopy Resolution 2.80 Å Mutation Yes [1]
PDB Sequence
TITIEEQIVL
40
VLKAKVQCEL
50
NITAQLQEGE
60
GNCFPEWDGL
70
ICWPRGTVGK
80

ISAVPCPPYI
90
YDFNHKGVAF
100
RHCNPNGTWD
110
FMHSLNKTWA
120
NYSDCLRFLQ
130

PDISIGKQEF
140
FERLYVMYTV
150
GYSISFGSLA
160
VAILIIGYFR
170
RLHCTRNYIH
180

MHLFVSFMLR
190
ATSIFVKDRV
200
VHAHIGVKEL
210
ESQYIGCKIA
239
VVMFIYFLAT
249

NYYWILVEGL
259
YLHNLIFVAF
269
FSDTKYLWGF
279
ILIGWGFPAA
289
FVAAWAVARA
299

TLADARCWEL
309
SAGDIKWIYQ
319
APILAAIGLN
329
FILFLNTVRV
339
LATKIWETDT
354

RKQYRKLAKS
364
TLVLVLVFGV
374
HYIVFVCLPG
388
LGWEIRMHCE
398
LFFNSFQGFF
408

VSIIYCYCNG
418
EVQAEVKKMW
428
SRWNLS
Residue
Distance (Å)
TYR178
3.660
MET181
3.435
HIS182
3.639
VAL185
4.014
LEU189
4.551
ILE234
3.726
LYS237
4.074
ILE238
4.409
VAL241
3.800
MET242
4.525
PHE246
4.633
TRP284
3.593
ALA288
4.841
Residue
Distance (Å)
ALA295
3.933
ALA299
4.086
LEU301
3.753
TRP307
3.701
ASP313
3.365
ILE314
4.251
TRP316
3.628
ILE317
3.711
ALA320
3.730
PRO321
3.843
LEU323
3.968
ALA324
3.853
GLY327
4.747
References  Top
REF 1 Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2101279118.

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