Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T21661 Target Info
Target Name Methionine synthase (MTR)
Synonyms Methionine synthase, vitamin-B12dependent; MTR; MS; Cobalamin-dependent methionine synthase; B12 dependent methionine synthetase; 5-methyltetrahydrofolate:homocysteine methyltransferase; 5-methyltetrahydrofolate-homocysteine methyltransferase; 5-methyltetrahydrofolate homocysteine methyltransferase
Target Type Literature-reported Target
Gene Name MTR
Biochemical Class Methyltransferase
UniProt ID
METH_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (6s)-5,6,7,8-Tetrahydrofolate Ligand Info
Structure Description Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains PDB:4CCZ
Method X-ray diffraction Resolution 2.70 Å Mutation No [1]
PDB Sequence
TLRDEINAIL
26
QKRIMVLDGG
36
MGTMIQREKL
46
EEHFRGQEFK
57
DHARPLKGNN
67

DILSITQPDV
77
IYQIHKEYLL
87
ADIIETNTFS
99
STSIAQADYG
109
LEHLAYRMNM
119

CSAGVARKAA
129
EEVTLQTGIK
139
RFVAGALGPT
149
NKTLSVSPSV
159
ERPDYRNITF
169

DELVEAYQEQ
179
AKGLLDGGVD
189
ILLIETIFDT
199
ANAKAALFAL
209
QNLFEEKYAP
219

RPIFISGTIV
229
DKSGRTLSGQ
239
TGEGFVISVS
249
HGEPLCIGLN
259
CALGAAEMRP
269

FIEIIGKCTT
279
AYVLCYPNAG
289
FAMDGLVNIV
320
GGCCGSTPDH
330
IREIAEAVKN
340

CKPRVPPATA
350
FEGHMLLSGL
360
EPFRIGPYTN
370
FVNIGERCNV
380
AGSRKFAKLI
390

MAGNYEEALC
400
VAKVQVEMGA
410
QVLDVNMDDG
420
MLDGPSAMTR
430
FCNLIASEPD
440

IAKVPLCIDS
450
SNFAVIEAGL
460
KCCQGKCIVN
470
SISLKEGEDD
480
FLEKARKIKK
490

YGAAMVVMAF
500
DEEGQATETD
510
TKIRVCTRAY
520
HLLVKKLGFN
530
PNDIIFDPNI
540

LTIGTGMEEH
550
NLYAINFIHA
560
TKVIKETLPG
570
ARISGGLSNL
580
SFSFRGMEAI
590

REAMHGVFLY
600
HAIKSGMDMG
610
IVNAGNLPVY
620
DDIHKELLQL
630
CEDLIWNKDP
640

EATEKLLRYA
650
Q
Residue
Distance (Å)
GLU376
3.522
ARG377
3.745
ASN379
3.678
GLY382
2.968
SER383
3.880
ARG384
3.108
ASP414
4.706
ASN416
4.794
ASP449
3.102
ASN470
3.136
VAL496
4.087
Residue
Distance (Å)
MET498
3.298
ASP537
2.714
ILE540
4.404
GLY575
4.765
GLY576
3.620
SER578
3.402
ASN579
2.739
PHE582
3.324
ARG585
2.881
ARG591
2.702
ILE611
3.598
References  Top
REF 1 Crystal Structure of Human 5-Methyltetrahydrofolate-Homocysteine Methyltransferase, the Homocysteine and Folate Binding Domains

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