Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T21580 | Target Info | |||
| Target Name | GTPase activating protein (RASA1) | ||||
| Synonyms | p120GAP; RasGAP; Ras p21 protein activator; Ras GTPase-activating protein 1; RASA; GTPase-activating protein; GAP | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | RASA1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Guanosine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | RAS-RASGAP COMPLEX | PDB:1WQ1 | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
MPEEEYSEFK
727 ELILQKELHV737 VYALSHVCGQ747 DRTLLASILL757 RIFLHEKLES767 LLLCTLNDRE 777 ISMEDEATTL787 FRATTLASTL797 MEQYMKATAT807 QFVHHALKDS817 ILKIMESKQS 827 CELSPSKLEK837 NEDVNTNLTH847 LLNILSELVE857 KIFMASEILP867 PTLRYIYGCL 877 QKSVQHKWPT887 NTTMRTRVVS897 GFVFLRLICP907 AILNPRMFNI917 ISDSPSPIAA 927 RTLILVAKSV937 QNLANLVEFG947 AKEPYMEGVN957 PFIKSNKHRM967 IMFLDELGNV 977 PELPDTTEHS987 RTDLSRDLAA997 LHEICVAHSD1007 ELRTLSNERG1017 AQQHVLKKLL 1027 AITELLQQKQ1037
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| Ligand Name: Aluminum fluoride | Ligand Info | |||||
| Structure Description | RAS-RASGAP COMPLEX | PDB:1WQ1 | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
MPEEEYSEFK
727 ELILQKELHV737 VYALSHVCGQ747 DRTLLASILL757 RIFLHEKLES767 LLLCTLNDRE 777 ISMEDEATTL787 FRATTLASTL797 MEQYMKATAT807 QFVHHALKDS817 ILKIMESKQS 827 CELSPSKLEK837 NEDVNTNLTH847 LLNILSELVE857 KIFMASEILP867 PTLRYIYGCL 877 QKSVQHKWPT887 NTTMRTRVVS897 GFVFLRLICP907 AILNPRMFNI917 ISDSPSPIAA 927 RTLILVAKSV937 QNLANLVEFG947 AKEPYMEGVN957 PFIKSNKHRM967 IMFLDELGNV 977 PELPDTTEHS987 RTDLSRDLAA997 LHEICVAHSD1007 ELRTLSNERG1017 AQQHVLKKLL 1027 AITELLQQKQ1037
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science. 1997 Jul 18;277(5324):333-8. | ||||
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