Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T20776 | Target Info | |||
Target Name | Fru-2,6-P2ase 2/6PF-2-K (PFK/FBPase 2) | ||||
Synonyms | PFKFB2; PFK-2/FBPase-2; 6PF-2-K/Fru-2,6-P2ASE heart-typeisozyme | ||||
Target Type | Literature-reported Target | ||||
Gene Name | PFKFB2 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Adenosine triphosphate | Ligand Info | |||||
Structure Description | Human Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2) | PDB:5HTK | ||||
Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [1] |
PDB Sequence |
ASYMTNSPTL
40 IVMIGLPARG50 KTYVSKKLTR60 YLNWIGVPTK70 VFNLGVYRRE80 AVKSYKSYDF 90 FRHDNEEAMK100 IRKQCALVAL110 EDVKAYLTEE120 NGQIAVFDAT130 NTTRERRDMI 140 LNFAEQNSFK150 VFFVESVCDD160 PDVIAANILE170 VKVSSPDYPE180 RNRENVMEDF 190 LKRIECYKVT200 YRPLDPDNYD210 KDLSFIKVIN220 VGQRFLVNRV230 QDYIQSKIVY 240 YLMNIHVQPR250 TIYLCRGESE261 FNLLGKIGGD271 SGLSVRGKQF281 AQALRKFLEE 291 QEITDLKVWT301 SQLKRTIQTA311 ESLGVPYEQW321 KILNEIDAGV331 CEEMTYAEIE 341 KRYPEEFALR351 DQEKYLYRYP361 GGESYQDLVQ371 RLEPVIMELE381 RQGNVLVISH 391 QAVMRCLLAY401 FLDKGADELP411 YLRCPLHTIF421 KLTPVAYGCK431 VETIKLNVEA 441 VNTHRDKPTN451 NFPK
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LEU46
4.122
PRO47
2.748
ALA48
2.278
ARG49
2.130
GLY50
2.054
LYS51
1.922
THR52
2.123
TYR53
4.271
ASN73
3.543
VAL76
2.996
ARG79
2.755
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Ligand Name: 1-Phosphono-L-histidine | Ligand Info | |||||
Structure Description | Human Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2) | PDB:5HTK | ||||
Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [1] |
PDB Sequence |
ASYMTNSPTL
40 IVMIGLPARG50 KTYVSKKLTR60 YLNWIGVPTK70 VFNLGVYRRE80 AVKSYKSYDF 90 FRHDNEEAMK100 IRKQCALVAL110 EDVKAYLTEE120 NGQIAVFDAT130 NTTRERRDMI 140 LNFAEQNSFK150 VFFVESVCDD160 PDVIAANILE170 VKVSSPDYPE180 RNRENVMEDF 190 LKRIECYKVT200 YRPLDPDNYD210 KDLSFIKVIN220 VGQRFLVNRV230 QDYIQSKIVY 240 YLMNIHVQPR250 TIYLCRGESE261 FNLLGKIGGD271 SGLSVRGKQF281 AQALRKFLEE 291 QEITDLKVWT301 SQLKRTIQTA311 ESLGVPYEQW321 KILNEIDAGV331 CEEMTYAEIE 341 KRYPEEFALR351 DQEKYLYRYP361 GGESYQDLVQ371 RLEPVIMELE381 RQGNVLVISH 391 QAVMRCLLAY401 FLDKGADELP411 YLRCPLHTIF421 KLTPVAYGCK431 VETIKLNVEA 441 VNTHRDKPTN451 NFPK
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Ligand Name: beta-D-Fructose 6-phosphate | Ligand Info | |||||
Structure Description | Human Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2) | PDB:5HTK | ||||
Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [1] |
PDB Sequence |
ASYMTNSPTL
40 IVMIGLPARG50 KTYVSKKLTR60 YLNWIGVPTK70 VFNLGVYRRE80 AVKSYKSYDF 90 FRHDNEEAMK100 IRKQCALVAL110 EDVKAYLTEE120 NGQIAVFDAT130 NTTRERRDMI 140 LNFAEQNSFK150 VFFVESVCDD160 PDVIAANILE170 VKVSSPDYPE180 RNRENVMEDF 190 LKRIECYKVT200 YRPLDPDNYD210 KDLSFIKVIN220 VGQRFLVNRV230 QDYIQSKIVY 240 YLMNIHVQPR250 TIYLCRGESE261 FNLLGKIGGD271 SGLSVRGKQF281 AQALRKFLEE 291 QEITDLKVWT301 SQLKRTIQTA311 ESLGVPYEQW321 KILNEIDAGV331 CEEMTYAEIE 341 KRYPEEFALR351 DQEKYLYRYP361 GGESYQDLVQ371 RLEPVIMELE381 RQGNVLVISH 391 QAVMRCLLAY401 FLDKGADELP411 YLRCPLHTIF421 KLTPVAYGCK431 VETIKLNVEA 441 VNTHRDKPTN451 NFPK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .F6P or .F6P2 or .F6P3 or :3F6P;style chemicals stick;color identity;select .A:256 or .A:263 or .A:267 or .A:268 or .A:269 or .A:306 or .A:326 or .A:327 or .A:329 or .A:337 or .A:351 or .A:355 or .A:360 or .A:366 or .A:391 or .A:392 or .A:393 or .A:396 or .A:411 or .A:444 or .A:446; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ARG256
2.729
ASN263
2.489
LYS267
4.305
ILE268
2.292
GLY269
2.027
ARG306
3.398
GLU326
2.136
ILE327
2.762
ALA329
4.044
TYR337
1.785
ARG351
1.910
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References | Top | ||||
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REF 1 | Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding. Proteins. 2017 Jan;85(1):117-124. |
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