Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T20761 Target Info
Target Name Vascular endothelial growth factor A (VEGFA)
Synonyms Vascular permeability factor; VPF; VEGF-A; VEGF
Target Type Successful Target
Gene Name VEGFA
Biochemical Class Growth factor
UniProt ID
VEGFA_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Trifluoroacetic Acid Ligand Info
Structure Description The crystal structure of chemically synthesized VEGF-A PDB:3QTK
Method X-ray diffraction Resolution 1.85 Å Mutation No [1]
PDB Sequence
VVKFMDVYQR
16
SYCHPIETLV
26
DIFQEYPDEI
36
EYIFKPSCVP
46
LMRCGGCCND
56

EGLECVPTEE
66
SNITMQIMRI
76
KPHQGQHIGE
86
MSFLQHNKCE
96
CRPKKD
Residue
Distance (Å)
GLU23
3.952
LEU25
3.214
VAL26
4.101
ASP27
4.094
TYR38
4.411
CYS44
3.950
PRO46
2.749
LEU47
3.819
MET48
3.969
ILE69
3.677
Residue
Distance (Å)
MET71
4.081
ARG75
3.700
ILE76
4.677
LYS77
4.020
GLN80
2.598
GLY81
3.200
GLN82
2.916
HIS83
2.606
GLN91
2.901
References  Top
REF 1 Total chemical synthesis of biologically active vascular endothelial growth factor. Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8029-33.

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