Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T18784 | Target Info | |||
| Target Name | Lysine-specific demethylase 7A (KDM7A) | ||||
| Synonyms | Lysine-specific demethylase 7; KIAA1718; KDM7; JmjC domain-containing histone demethylation protein 1D; JHDM1D | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KDM7A | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(carboxymethylamino)-2-oxoacetic acid | Ligand Info | |||||
| Structure Description | Structure of KIAA1718 Jumonji domain in complex with N-oxalylglycine | PDB:3KVB | ||||
| Method | X-ray diffraction | Resolution | 2.69 Å | Mutation | No | [1] |
| PDB Sequence |
PVQAGTRTFI
123 KELRSRVFPS133 ADEIIIKMHG143 SQLTQRYLEK153 HGFDVPIMVP163 KLDDLGLRLP 173 SPTFSVMDVE183 RYVGGDKVID193 VIDVARQADS203 KMTLHNYVKY213 FMNPNRPKVL 223 NVISLEFSDT233 KMSELVEVPD243 IAKKLSWVEN253 YWPDDSVFPK263 PFVQKYCLMG 273 VQDSYTDFHI283 DFGGTSVWYH293 VLWGEKIFYL303 IKPTDENLAR313 YESWSSSVTQ 323 SEVFFGDKVD333 KCYKCVVKQG343 HTLFVPTGWI353 HAVLTSQDCM363 AFGGNFLHNL 373 NIGMQLRCYE383 MEKRLKTPDL393 FKFPFFEAIC403 WFVAKNLLET413 LKELREDGFQ 423 PQTYLVQGVK433 ALHTALKLWM443 KKELVSEHAF453 EIPDNVRPGH463 LIKELSKVIR 473 AIEEEN
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| Ligand Name: Alpha-ketoglutaric acid | Ligand Info | |||||
| Structure Description | E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase | PDB:3U78 | ||||
| Method | X-ray diffraction | Resolution | 2.69 Å | Mutation | No | [2] |
| PDB Sequence |
PVQAGTRTFI
123 KELRSRVFPS133 ADEIIIKMHG143 SQLTQRYLEK153 HGFDVPIMVP163 KLDDLGLRLP 173 SPTFSVMDVE183 RYVGGDKVID193 VIDVARQADS203 KMTLHNYVKY213 FMNPNRPKVL 223 NVISLEFSDT233 KMSELVEVPD243 IAKKLSWVEN253 YWPDDSVFPK263 PFVQKYCLMG 273 VQDSYTDFHI283 DFGGTSVWYH293 VLWGEKIFYL303 IKPTDENLAR313 YESWSSSVTQ 323 SEVFFGDKVD333 KCYKCVVKQG343 HTLFVPTGWI353 HAVLTSQDCM363 AFGGNFLHNL 373 NIGMQLRCYE383 MEKRLKTPDL393 FKFPFFEAIC403 WFVAKNLLET413 LKELREDGFQ 423 PQTYLVQGVK433 ALHTALKLWM443 KKELVSEHAF453 EIPDNVRPGH463 LIKELSKVIR 473 AIEEEN
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 7-[(5-Aminopentyl)oxy]-N~4~-(1-Benzylpiperidin-4-Yl)-N~2~-[3-(Dimethylamino)propyl]-6-Methoxyquinazoline-2,4-Diamine | Ligand Info | |||||
| Structure Description | E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase | PDB:3U78 | ||||
| Method | X-ray diffraction | Resolution | 2.69 Å | Mutation | No | [2] |
| PDB Sequence |
PVQAGTRTFI
123 KELRSRVFPS133 ADEIIIKMHG143 SQLTQRYLEK153 HGFDVPIMVP163 KLDDLGLRLP 173 SPTFSVMDVE183 RYVGGDKVID193 VIDVARQADS203 KMTLHNYVKY213 FMNPNRPKVL 223 NVISLEFSDT233 KMSELVEVPD243 IAKKLSWVEN253 YWPDDSVFPK263 PFVQKYCLMG 273 VQDSYTDFHI283 DFGGTSVWYH293 VLWGEKIFYL303 IKPTDENLAR313 YESWSSSVTQ 323 SEVFFGDKVD333 KCYKCVVKQG343 HTLFVPTGWI353 HAVLTSQDCM363 AFGGNFLHNL 373 NIGMQLRCYE383 MEKRLKTPDL393 FKFPFFEAIC403 WFVAKNLLET413 LKELREDGFQ 423 PQTYLVQGVK433 ALHTALKLWM443 KKELVSEHAF453 EIPDNVRPGH463 LIKELSKVIR 473 AIEEEN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .E67 or .E672 or .E673 or :3E67;style chemicals stick;color identity;select .A:195 or .A:200 or .A:202 or .A:226 or .A:278 or .A:279 or .A:280 or .A:282 or .A:283 or .A:284 or .A:285 or .A:323 or .A:389 or .A:390 or .A:391 or .A:392 or .A:395; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol. 2010 Jan;17(1):38-43. | ||||
| REF 2 | An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol. 2012 Feb 24;416(3):319-27. | ||||
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