Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17980 | Target Info | |||
| Target Name | Fyn tyrosine protein kinase (FYN) | ||||
| Synonyms | Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Fyn p59-Fyn; Fyn Protooncogene Syn | ||||
| Target Type | Successful Target | ||||
| Gene Name | FYN | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Phosphonotyrosine | Ligand Info | |||||
| Structure Description | Crystal Structure of Fyn kinase domain complexed with staurosporine | PDB:2DQ7 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
KDVWEIPRES
10 LQLIKRLGNG20 QFGEVWMGTW30 NGNTKVAIKT40 LKPGTMSPES50 FLEEAQIMKK 60 LKHDKLVQLY70 AVVSEEPIYI80 VTEYMNKGSL90 LDFLKDGEGR100 ALKLPNLVDM 110 AAQVAAGMAY120 IERMNYIHRD130 LRSANILVGN140 GLICKIADFG150 LARLIEDNET 161 ARQGAKFPIK171 WTAPEAALYG181 RFTIKSDVWS191 FGILLTELVT201 KGRVPYPGMN 211 NREVLEQVER221 GYRMPCPQDC231 PISLHELMIH241 CWKKDPEERP251 TFEYLQSFLE 261 DY
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| Ligand Name: Staurosporine | Ligand Info | |||||
| Structure Description | Crystal Structure of Fyn kinase domain complexed with staurosporine | PDB:2DQ7 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
KDVWEIPRES
10 LQLIKRLGNG20 QFGEVWMGTW30 NGNTKVAIKT40 LKPGTMSPES50 FLEEAQIMKK 60 LKHDKLVQLY70 AVVSEEPIYI80 VTEYMNKGSL90 LDFLKDGEGR100 ALKLPNLVDM 110 AAQVAAGMAY120 IERMNYIHRD130 LRSANILVGN140 GLICKIADFG150 LARLIEDNET 161 ARQGAKFPIK171 WTAPEAALYG181 RFTIKSDVWS191 FGILLTELVT201 KGRVPYPGMN 211 NREVLEQVER221 GYRMPCPQDC231 PISLHELMIH241 CWKKDPEERP251 TFEYLQSFLE 261 DY
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| Ligand Name: 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane | Ligand Info | |||||
| Structure Description | Crystal structure of the human Fyn SH3 R96W mutant | PDB:3H0F | ||||
| Method | X-ray diffraction | Resolution | 2.61 Å | Mutation | Yes | [2] |
| PDB Sequence |
VTLFVALYDY
93 EAWTEDDLSF103 HKGEKFQILN113 SSEGDWWEAR123 SLTTGETGYI133 PSNYVAPVD |
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human Fyn kinase domain complexed with staurosporine. Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. | ||||
| REF 2 | Synergy and allostery in ligand binding by HIV-1 Nef. Biochem J. 2021 Apr 30;478(8):1525-1545. | ||||
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