Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T17367 Target Info
Target Name Sequestosome-1 p62 (SQSTM1)
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Target Type Literature-reported Target
Gene Name SQSTM1
Biochemical Class Zinc-finger
UniProt ID
SQSTM_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Arginine Ligand Info
Structure Description Crystal structure of p62 ZZ domain in complex with free arginine PDB:6MJ7
Method X-ray diffraction Resolution 1.41 Å Mutation No [1]
PDB Sequence
GSNMVHPNVI
127
CDGCNGPVVG
137
TRYKCSVCPD
147
YDLCSVCEGK
157
GLHRGHTKLA
167

FPSP
Residue
Distance (Å)
ASN125
3.938
VAL126
3.442
ILE127
2.832
CYS128
3.682
ASP129
2.795
Residue
Distance (Å)
ASN132
3.018
ASP147
3.317
TYR148
4.416
ASP149
2.680
References  Top
REF 1 ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun. 2018 Oct 22;9(1):4373.

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