Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17221 | Target Info | |||
| Target Name | Glutathione S-transferase A1 (GSTA1) | ||||
| Synonyms | GTH1; GSTA1-1; GST-epsilon; GST class-alpha member 1; GST HA subunit 1; Androst-5-ene-3,17-dione isomerase; 13-hydroperoxyoctadecadienoate peroxidase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GSTA1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | Crystal structure of hGSTA1-1 complexed with GSH and MPD in each subunit | PDB:6ATO | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [1] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221 F
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Ethacrynic acid | Ligand Info | |||||
| Structure Description | GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K) | PDB:1GSE | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [2] |
| PDB Sequence |
AEKPKLHYFN
11 ARGKMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221 F
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cysteine Sulfenic Acid | Ligand Info | |||||
| Structure Description | Crystal structure of human glutathione transferase (GST) A1-1 in complex with a decarboxy-glutathione | PDB:1PL1 | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | Yes | [3] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 PPEEKDAKLA122 LIKEKIKNRY132 FPAFEKVLKS142 HGQDYLVGNK152 LSRADIHLVE 162 LLYYVEELDS172 SLISSFPLLK182 ALKTRISNLP192 TVKKFLQPGS202 PRKPPMDEKS 212 LEEARKIFRF222
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSO or .CSO2 or .CSO3 or :3CSO;style chemicals stick;color identity;select .A:108 or .A:109 or .A:110 or .A:111 or .A:113 or .A:114 or .A:116 or .A:117 or .A:120; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: S-hexylglutathione | Ligand Info | |||||
| Structure Description | Crystal Structure Analysis of human Glutathione S-transferase with S-hexyl glutatione and glycerol at 1.3 Angstrom | PDB:1K3Y | ||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [4] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221 F
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GTX or .GTX2 or .GTX3 or :3GTX;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:107 or .A:108 or .A:110 or .A:111 or .A:208 or .A:213 or .A:216 or .A:220 or .A:222; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR9
3.179
PHE10
4.756
GLY14
4.774
ARG15
3.833
LEU41
4.564
ARG45
2.998
GLN53
4.344
GLN54
3.073
VAL55
2.733
PRO56
3.675
GLN67
2.866
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: S-Benzyl-Glutathione | Ligand Info | |||||
| Structure Description | Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the MU and PI class enzymes | PDB:1GUH | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [5] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221 F
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GSB or .GSB2 or .GSB3 or :3GSB;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:66 or .A:67 or .A:68 or .A:69 or .A:107 or .A:108 or .A:111 or .A:208 or .A:216 or .A:220 or .A:222; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine | Ligand Info | |||||
| Structure Description | Crystal structure of human glutathione transferase (GST) A1-1 in complex with a decarboxy-glutathione | PDB:1PL1 | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | Yes | [3] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 PPEEKDAKLA122 LIKEKIKNRY132 FPAFEKVLKS142 HGQDYLVGNK152 LSRADIHLVE 162 LLYYVEELDS172 SLISSFPLLK182 ALKTRISNLP192 TVKKFLQPGS202 PRKPPMDEKS 212 LEEARKIFRF222
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ABY or .ABY2 or .ABY3 or :3ABY;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:107 or .A:108 or .A:110 or .A:111 or .A:208 or .A:213 or .A:216 or .A:220 or .A:222; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2-Hydroxyethyl disulfide | Ligand Info | |||||
| Structure Description | Crystal structure of human glutathione transferase (GST) A1-1 in complex with glutathione | PDB:1PKW | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [3] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 PPEEKDAKLA122 LIKEKIKNRY132 FPAFEKVLKS142 HGQDYLVGNK152 LSRADIHLVE 162 LLYYVEELDS172 SLISSFPLLK182 ALKTRISNLP192 TVKKFLQPGS202 PRKPPMDEKS 212 LEEARKIFRF222
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HED or .HED2 or .HED3 or :3HED;style chemicals stick;color identity;select .A:18 or .A:68 or .A:69 or .A:72 or .A:96 or .A:97 or .A:99 or .A:100 or .A:155 or .A:159 or .A:162; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2~{R})-2-azanyl-5-[[(2~{R})-3-(hexylcarbamothioylsulfanyl)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human GSTA1-1 bound to the glutathione adduct of hexyl-isothiocyanate | PDB:7BIB | ||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [6] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TZ8 or .TZ82 or .TZ83 or :3TZ8;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:69 or .A:107 or .A:108 or .A:111; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human GSTA1-1 bound to the glutathione adduct of cinnamaldehyde | PDB:6YAW | ||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [7] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .P9H or .P9H2 or .P9H3 or :3P9H;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:107 or .A:108 or .A:111 or .A:208 or .A:216 or .A:220; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid | Ligand Info | |||||
| Structure Description | Human GST A1-1-GIMF with GSDHN | PDB:3IK9 | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [8] |
| PDB Sequence |
AEKPKLHYFN
11 GRGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMIIMLPF 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPPDEI 211 YVRTVYNIF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BOB or .BOB2 or .BOB3 or :3BOB;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:107 or .A:108 or .A:111 or .A:212 or .A:216 or .A:217 or .A:220; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Amino-5-[1-(carboxylatomethylcarbamoyl)-2-nitrososulfanyl-ethyl]amino-5-oxo-pentanoate | Ligand Info | |||||
| Structure Description | Crystal structure of hGSTA1-1 complexed with two GSH analogues in each subunit | PDB:6ATR | ||||
| Method | X-ray diffraction | Resolution | 1.29 Å | Mutation | No | [9] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221 F
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GSN or .GSN2 or .GSN3 or :3GSN;style chemicals stick;color identity;select .A:9 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:220; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Norophthalamic acid | Ligand Info | |||||
| Structure Description | Crystal structure of hGSTA1-1 complexed with two GSH analogues in each subunit | PDB:6ATR | ||||
| Method | X-ray diffraction | Resolution | 1.29 Å | Mutation | No | [9] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 CPPEEKDAKL121 ALIKEKIKNR131 YFPAFEKVLK141 SHGQDYLVGN151 KLSRADIHLV 161 ELLYYVEELD171 SSLISSFPLL181 KALKTRISNL191 PTVKKFLQPG201 SPRKPPMDEK 211 SLEEARKIFR221 F
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BWS or .BWS2 or .BWS3 or :3BWS;style chemicals stick;color identity;select .A:9 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:220; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: L-Gamma-Glutamyl-S-[(2-Phenylethyl)carbamothioyl]-L-Cysteinylglycine | Ligand Info | |||||
| Structure Description | Crystal Structure of hGSTA1-1 with Glutathione Adduct of Phenethyl Isothiocyanate and Cystein Adduct of Phenethyl Isothiocyanate | PDB:5JCU | ||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [10] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 PPEEKDAKLA122 LIKEKIKNRY132 FPAFEKVLKS142 HGQDYLVGNK152 LSRADIHLVE 162 LLYYVEELDS172 SLISSFPLLK182 ALKTRISNLP192 TVKKFLQPGS202 PRKPPMDEKS 212 LEEARKIFRF222
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GVX or .GVX2 or .GVX3 or :3GVX;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:107 or .A:108 or .A:110 or .A:111 or .A:208 or .A:213 or .A:216 or .A:220 or .A:222; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR9
2.501
PHE10
3.949
GLY14
4.061
ARG15
3.927
LEU41
4.768
ARG45
3.007
GLN53
4.510
GLN54
3.034
VAL55
2.732
PRO56
3.796
GLN67
2.884
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| Ligand Name: S-[(2-phenylethyl)carbamothioyl]-L-cysteine | Ligand Info | |||||
| Structure Description | Crystal Structure of hGSTA1-1 with Glutathione Adduct of Phenethyl Isothiocyanate and Cystein Adduct of Phenethyl Isothiocyanate | PDB:5JCU | ||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [10] |
| PDB Sequence |
AEKPKLHYFN
11 ARGRMESTRW21 LLAAAGVEFE31 EKFIKSAEDL41 DKLRNDGYLM51 FQQVPMVEID 61 GMKLVQTRAI71 LNYIASKYNL81 YGKDIKERAL91 IDMYIEGIAD101 LGEMILLLPV 111 PPEEKDAKLA122 LIKEKIKNRY132 FPAFEKVLKS142 HGQDYLVGNK152 LSRADIHLVE 162 LLYYVEELDS172 SLISSFPLLK182 ALKTRISNLP192 TVKKFLQPGS202 PRKPPMDEKS 212 LEEARKIFRF222
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6M6 or .6M62 or .6M63 or :36M6;style chemicals stick;color identity;select .A:104 or .A:105 or .A:108 or .A:109 or .A:110 or .A:111 or .A:113 or .A:114 or .A:116 or .A:117 or .A:120; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: L-Gamma-Glutamyl-S-(2-{[4-(3-Carboxypropyl)phenyl](2-Chloroethyl)amino}ethyl)-L-Cysteinylglycine | Ligand Info | |||||
| Structure Description | Crystal Structure Analysis of GSTA1-1 in complex with chlorambucil | PDB:4HJ2 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [11] |
| PDB Sequence |
KPKLHYFNAR
13 GRMESTRWLL23 AAAGVEFEEK33 FIKSAEDLDK43 LRNDGYLMFQ53 QVPMVEIDGM 63 KLVQTRAILN73 YIASKYNLYG83 KDIKERALID93 MYIEGIADLG103 EMILLLPVCP 113 PEEKDAKLAL123 IKEKIKNRYF133 PAFEKVLKSH143 GQDYLVGNKL153 SRADIHLVEL 163 LYYVEELDSS173 LISSFPLLKA183 LKTRISNLPT193 VKKFLQPGSP203 RKPPMDEKSL 213 EEARKIF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LZ6 or .LZ62 or .LZ63 or :3LZ6;style chemicals stick;color identity;select .A:9 or .A:10 or .A:14 or .A:15 or .A:41 or .A:45 or .A:53 or .A:54 or .A:55 or .A:56 or .A:67 or .A:68 or .A:106 or .A:107 or .A:108 or .A:109 or .A:110 or .A:111 or .A:208 or .A:213 or .A:216 or .A:220; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR9
2.647
PHE10
4.008
GLY14
3.913
ARG15
3.585
LEU41
4.815
ARG45
2.963
GLN53
4.341
GLN54
3.116
VAL55
2.711
PRO56
3.904
GLN67
2.994
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The dynamic nature of hGSTA1-1 C-terminal helix | ||||
| REF 2 | Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate. Structure. 1995 Jul 15;3(7):717-27. | ||||
| REF 3 | New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix. Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):197-207. | ||||
| REF 4 | 1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site. Proteins. 2002 Sep 1;48(4):618-27. | ||||
| REF 5 | Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes. J Mol Biol. 1993 Jul 5;232(1):192-212. | ||||
| REF 6 | Role of human salivary enzymes in bitter taste perception. Food Chem. 2022 Aug 30;386:132798. | ||||
| REF 7 | Interactions Between Odorants and Glutathione Transferases in the Human Olfactory Cleft. Chem Senses. 2020 Nov 7;45(8):645-654. | ||||
| REF 8 | Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry. 2010 Feb 23;49(7):1541-8. | ||||
| REF 9 | hGSTA1 apo structure and dynamic c-terminus helix | ||||
| REF 10 | Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical. PLoS One. 2016 Sep 29;11(9):e0163821. | ||||
| REF 11 | The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysis. PLoS One. 2013;8(2):e56337. | ||||
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