Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17134 | Target Info | |||
| Target Name | RET M918T mutant (RET M918T) | ||||
| Synonyms | RET51 M918T mutant; Proto-oncogene tyrosine-protein kinase receptor Ret M918T mutant; Proto-oncogene c-Ret M918T mutant; PTC M918T mutant; Cadherin family member 12 M918T mutant; CDHR16 M918T mutant; CDHF12 M918T mutant | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | RET | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine | Ligand Info | |||||
| Structure Description | Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine | PDB:4CKI | ||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPLSLSVDAF
709 KILEDPKWEF719 PRKNLVLGKT729 LGEGEFGKVV739 KATAFHLKGR749 AGYTTVAVKM 759 LKENASPSEL769 RDLLSEFNVL779 KQVNHPHVIK789 LYGACSQDGP799 LLLIVEYAKY 809 GSLRGFLRES819 RKVDERALTM848 GDLISFAWQI858 SQGMQYLAEM868 KLVHRDLAAR 878 NILVAEGRKM888 KISDFGLSRD898 VEEDSVKRSQ910 GRIPVKWTAI920 ESLFDHIYTT 930 QSDVWSFGVL940 LWEIVTLGGN950 PYPGIPPERL960 FNLLKTGHRM970 ERPDNCSEEM 980 YRLMLQCWKQ990 EPDKRPVFAD1000 ISKDLEKMMV1010 KRR
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| Ligand Name: Phosphonotyrosine | Ligand Info | |||||
| Structure Description | Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine | PDB:4CKI | ||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPLSLSVDAF
709 KILEDPKWEF719 PRKNLVLGKT729 LGEGEFGKVV739 KATAFHLKGR749 AGYTTVAVKM 759 LKENASPSEL769 RDLLSEFNVL779 KQVNHPHVIK789 LYGACSQDGP799 LLLIVEYAKY 809 GSLRGFLRES819 RKVDERALTM848 GDLISFAWQI858 SQGMQYLAEM868 KLVHRDLAAR 878 NILVAEGRKM888 KISDFGLSRD898 VEEDSVKRSQ910 GRIPVKWTAI920 ESLFDHIYTT 930 QSDVWSFGVL940 LWEIVTLGGN950 PYPGIPPERL960 FNLLKTGHRM970 ERPDNCSEEM 980 YRLMLQCWKQ990 EPDKRPVFAD1000 ISKDLEKMMV1010 KRR
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol Cell. 2014 Mar 6;53(5):738-51. | ||||
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