Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16808 | Target Info | |||
| Target Name | Protein arginine methyltransferase 1 (PRMT1) | ||||
| Synonyms | Protein arginine N-methyltransferase 1; Interferon receptor 1-bound protein 4; IR1B4; Histone-arginine N-methyltransferase PRMT1; HRMT1L2; HMT2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PRMT1 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: GSK3368715 | Ligand Info | |||||
| Structure Description | type 1 PRMT in complex with the inhibitor GSK3368715 | PDB:6NT2 | ||||
| Method | X-ray diffraction | Resolution | 2.48 Å | Mutation | No | [1] |
| PDB Sequence |
PNAEDMTSKD
51 YYFDSYAHFG61 IHEEMLKDEV71 RTLTYRNSMF81 HNRHLFKDKV91 VLDVGSGTGI 101 LCMFAAKAGA111 RKVIGIECSS121 ISDYAVKIVK131 ANKLDHVVTI141 IKGKVEEVEL 151 PVEKVDIIIS161 EWMGYCLFYE171 SMLNTVLYAR181 DKWLAPDGLI191 FPDRATLYVT 201 AIEDRQYKDY211 KIHWWENVYG221 FDMSCIKDVA231 IKEPLVDVVD241 PKQLVTNACL 251 IKEVDIYTVK261 VEDLTFTSPF271 CLQVKRNDYV281 HALVAYFNIE291 FTRCHKRTGF 301 STSPESPYTH311 WKQTVFYMED321 YLTVKTGEEI331 FGTIGMRPNA341 KNNRDLDFTI 351 DLDFKGQLCE361 LSCSTDYRMR371
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 Jul 8;36(1):100-114.e25. | ||||
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