Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T16601 Target Info
Target Name Carcinoembryonic antigen CEA (CD66e)
Synonyms Meconium antigen 100; Carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e antigen
Target Type Clinical trial Target
Gene Name CEACAM5
Biochemical Class Immunoglobulin
UniProt ID
CEAM5_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (1-Oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate Ligand Info
Structure Description Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA) PDB:2VER
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
KLTIESTPFN
10
VAEGKEVLLL
20
VHNLPQHLFG
30
YSWYKGERCD
40
GNCQIIGYVI
50

GTQCATPGPA
60
YSGREIIYPN
70
ASLLIQNIIQ
80
NDTGFYTLHV
90
IKSDLVNEEA
100

TGQFRVYPEL
110
Residue
Distance (Å)
LYS35
2.923
CYS39
2.029
ASN42
3.781
CYS43
2.031
VAL49
3.319
THR52
1.865
CYS54
2.033
PRO59
2.505
ALA60
2.341
Residue
Distance (Å)
ASN81
4.022
HIS89
2.237
ILE91
4.536
LEU95
3.000
VAL96
3.539
ASN97
1.942
GLU98
3.346
GLU99
2.833
References  Top
REF 1 Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation. Mol Microbiol. 2008 Jan;67(2):420-34.

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