Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T16188 Target Info
Target Name Unc-51 like kinase 3 (ULK3)
Synonyms Unc-51-like kinase 3; Serine/threonine-protein kinase ULK3
Target Type Literature-reported Target
Gene Name ULK3
UniProt ID
ULK3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Bosutinib Ligand Info
Structure Description Unc-51-Like Kinase 3 (ULK3) In Complex With Bosutinib PDB:6FDY
Method X-ray diffraction Resolution 1.70 Å Mutation No [1]
PDB Sequence
PRLDGFILTE
18
RLGATVYKAY
32
AKKDTREVVA
42
IKCVAKKSLN
52
KASVENLLTE
62

IEILKGIRHP
72
HIVQLKDFQW
82
DSDNIYLIME
92
FCAGGDLSRF
102
IHTRRILPEK
112

VARVFMQQLA
122
SALQFLHERN
132
ISHLDLKPQN
142
ILLSSLEKPH
152
LKLADFGFAQ
162

HMSPWDEKHV
172
LRGSPLYMAP
182
EMVCQRQYDA
192
RVDLWSMGVI
202
LYEALFGQPP
212

FASRSFSELE
222
EKIRSNRVIE
232
LPLRPLLSRD
242
CRDLLQRLLE
252
RDPSRRISFQ
262

DFFAHPWVDL
272
EH
Residue
Distance (Å)
LEU20
3.632
GLY21
4.466
VAL28
3.862
ALA42
3.608
ILE43
4.402
LYS44
3.918
VAL75
3.624
LEU89
4.675
MET91
3.630
GLU92
3.383
PHE93
3.716
CYS94
2.938
ALA95
3.802
GLY96
4.883
GLY97
4.151
Residue
Distance (Å)
GLN141
3.752
ASN142
3.490
LEU144
3.329
ALA156
4.235
ASP157
3.480
LEU173
3.533
PRO177
3.880
MET180
3.398
VAL185
3.975
PHE218
3.175
SER219
3.031
LEU221
3.723
GLU222
3.066
ILE225
3.743
Ligand Name: Momelotinib Ligand Info
Structure Description Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib PDB:6FDZ
Method X-ray diffraction Resolution 2.55 Å Mutation No [2]
PDB Sequence
PPRLDGFILT
17
ERLGSGTYAT
27
VYKAYAKKDT
37
REVVAIKCVA
47
KKSLNKASVE
57

NLLTEIEILK
67
GIRHPHIVQL
77
KDFQWDSDNI
87
YLIMEFCAGG
97
DLSRFIHTRR
107

ILPEKVARVF
117
MQQLASALQF
127
LHERNISHLD
137
LKPQNILLSS
147
LEKPHLKLAD
157

FGFAQHMSPW
167
DEKHVLRGSP
177
LYMAPEMVCQ
189
YDARVDLWSM
199
GVILYEALFG
209

QPPFASRSFS
219
ELEEKIRSNR
229
VIELPLRPLL
239
SRDCRDLLQR
249
LLERDPSRRI
259

SFQDFFAHPW
269
VDLEH
Residue
Distance (Å)
LEU20
3.472
GLY21
4.308
SER22
3.663
GLY23
3.437
ALA26
3.361
THR27
3.894
VAL28
3.657
ALA42
3.512
LYS44
2.712
VAL75
4.458
MET91
3.855
Residue
Distance (Å)
GLU92
3.162
PHE93
3.733
CYS94
2.744
ALA95
4.815
GLY97
3.776
ASP98
4.838
ARG101
3.902
LEU144
3.459
ASP157
4.541
PHE158
3.367
GLY159
4.973
References  Top
REF 1 Unc-51-Like Kinase 3 (ULK3) In Complex With Bosutinib
REF 2 Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib

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