Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15722 | Target Info | |||
| Target Name | Cyclin-dependent kinase 11B (CDK11B) | ||||
| Synonyms | p58 CLK1; p58 CLK-1; PK58; PITSLREA; PITSLRE serine/threonineprotein kinase CDC2L1; PITSLRE serine/threonine-protein kinase CDC2L1; Galactosyltransferaseassociated protein kinase p58/GTA; Galactosyltransferase-associated protein kinase p58/GTA; Cyclindependent kinase 11B; Cell division protein kinase 11B; Cell division cycle 2-like protein kinase 1; CLK-1; CDK11; CDC2L1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CDK11B | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: OTS964 | Ligand Info | |||||
| Structure Description | CDK11 in complex with small molecule inhibitor OTS964 | PDB:7UKZ | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
EEFQCLNRIE
89 EGTYGVVYRA99 KDKEIVALKR112 LKMEKEKEFP123 ITSLREINTI133 LKAQHPNIVT 143 VREIVVGSNM153 DKIYIVMNYV163 EHDLKSLMET173 MKQPFLPGEV183 KTLMIQLLRG 193 VKHLHDNWIL203 HRDLKTSNLL213 LSHAGILKVG223 DFGLAREYGS233 PLKAYPVVVT 244 LWYRAPELLL254 GAKEYSTAVD264 MWSVGCIFGE274 LLTQKPLFPG284 KSEIDQINKV 294 FKDLGTPSEK304 IWPGYSELPA314 VKKMTFSEHP324 YRKRFGALLS337 DQGFDLMNKF 347 LTYFPGRRIS357 AEDGLKHEYF367 RETPLPIDPS377 MFPKL
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ILE88
3.447
GLU89
3.680
GLU90
3.670
GLY91
3.611
GLY94
4.782
VAL96
3.509
ALA109
3.511
LYS111
4.533
VAL142
4.533
MET160
3.397
ASN161
3.839
|
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | CDK11 in complex with small molecule inhibitor OTS964 | PDB:7UKZ | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
EEFQCLNRIE
89 EGTYGVVYRA99 KDKEIVALKR112 LKMEKEKEFP123 ITSLREINTI133 LKAQHPNIVT 143 VREIVVGSNM153 DKIYIVMNYV163 EHDLKSLMET173 MKQPFLPGEV183 KTLMIQLLRG 193 VKHLHDNWIL203 HRDLKTSNLL213 LSHAGILKVG223 DFGLAREYGS233 PLKAYPVVVT 244 LWYRAPELLL254 GAKEYSTAVD264 MWSVGCIFGE274 LLTQKPLFPG284 KSEIDQINKV 294 FKDLGTPSEK304 IWPGYSELPA314 VKKMTFSEHP324 YRKRFGALLS337 DQGFDLMNKF 347 LTYFPGRRIS357 AEDGLKHEYF367 RETPLPIDPS377 MFPKL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964. Structure. 2022 Dec 1;30(12):1615-1625.e4. | ||||
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