Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T15514 Target Info
Target Name Hepatocyte nuclear factor 4-alpha (HNF4A)
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF14; TCF-14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF4; HNF-4-alpha
Target Type Literature-reported Target
Gene Name HNF4A
Biochemical Class Nuclear hormone receptor
UniProt ID
HNF4A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Lauric acid Ligand Info
Structure Description HNF4alpha in complex with the corepressor EBP1 fragment PDB:6CHT
Method X-ray diffraction Resolution 3.17 Å Mutation No [1]
PDB Sequence
SINALLQAEV
151
LAKKIASIAD
177
VCESMKEQLL
187
VLVEWAKYIP
197
AFCELPLDDQ
207

VALLRAHAGE
217
HLLLGATKRS
227
MVFKDVLLLG
237
NDYIVPRHCP
247
ELAEMSRVSI
257

RILDELVLPF
267
QELQIDDNEY
277
AYLKAIIFFD
287
PDAKGLSDPG
297
KIKRLRSQVQ
307

VSLEDYINDR
317
QYDSRGRFGE
327
LLLLLPTLQS
337
ITWQMIEQIQ
347
FIKLFGMAKI
357

DNLLQEMLLG
367
Residue
Distance (Å)
VAL178
4.255
SER181
3.352
MET182
4.432
GLN185
3.147
LEU219
4.018
GLY222
4.713
ALA223
3.679
ARG226
1.297
LEU235
3.361
Residue
Distance (Å)
LEU236
3.280
GLY237
2.860
LEU249
4.805
MET252
3.761
VAL255
3.677
SER256
4.669
ILE259
3.966
MET342
4.292
ILE346
4.833
Ligand Name: Myristic acid Ligand Info
Structure Description Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide PDB:1PZL
Method X-ray diffraction Resolution 2.10 Å Mutation Yes [2]
PDB Sequence
LASLPSINAL
146
LQAEVLSRQI
156
TNGDIRAKKI
172
ASIADVCESM
182
KEQLLVLVEW
192

AKYIPAFCEL
202
PLDDQVALLR
212
AHAGEHLLLG
222
ATKRSMVFKD
232
VLLLGNDYIV
242

PRHCPELAEM
252
SRVSIRILDE
262
LVLPFQELQI
272
DDNEYAYLKA
282
IIFFDPDAKG
292

LSDPGKIKRL
302
RSQVQVSLED
312
YINDRQYDSR
322
GRFGELLLLL
332
PTLQSITWQM
342

IEQIQFIKLF
352
GMAKIDNLLQ
362
EMLLGGS
Residue
Distance (Å)
VAL178
3.896
SER181
2.488
MET182
3.837
GLN185
3.560
LEU219
3.841
LEU220
4.035
GLY222
4.574
ALA223
3.586
ARG226
2.396
LEU234
3.954
LEU235
4.986
LEU236
3.601
Residue
Distance (Å)
GLY237
2.763
ASN238
4.788
VAL242
4.338
LEU249
4.662
MET252
4.355
VAL255
4.275
SER256
3.941
ILE259
3.753
MET342
4.022
GLN345
4.201
ILE346
4.203
ILE349
3.633
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 ErbB3-binding protein 1 (EBP1) represses HNF4Alpha-mediated transcription and insulin secretion in pancreatic beta-cells. J Biol Chem. 2019 Sep 20;294(38):13983-13994.
REF 2 Structural basis for HNF-4alpha activation by ligand and coactivator binding. J Biol Chem. 2004 May 28;279(22):23311-6.

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