Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T15033 Target Info
Target Name C-X3-C chemokine receptor 1 (CX3CR1)
Synonyms V28; GPR13; G-protein coupled receptor 13; Fractalkine receptor CX3CR1; Fractalkine receptor; CX3C chemokine receptor 1; CMKBRL1; CMKBLR1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; Beta chemokine receptor-like1; Beta chemokine receptor-like 1
Target Type Literature-reported Target
Gene Name CX3CR1
Biochemical Class GPCR rhodopsin
UniProt ID
CX3C1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1 PDB:7XBW
Method Electron microscopy Resolution 2.80 Å Mutation Yes [1]
PDB Sequence
IGDIVVFGTV
32
FLSIFYSVIF
42
AIGLVGNLLV
52
VFALTNSKKP
62
KSVTDIYLLN
72

LALSDLLFVA
82
TLPFWTHYLI
92
NEKGLHNAMC
102
KFTTAFFFIG
112
FFGSIFFLTV
122

ISIDRYLAIV
132
LAANSMNNRT
142
VQHGVTISLG
152
VWAAAILVAA
162
PQFMFTKQKE
172

NECLGDYPEV
182
LQEIWPVLRN
192
VETNFLGFLL
202
PLLIMSYCYF
212
RIIQTLFSSK
222

NHKKAKAIKL
232
ILLVVIVFFL
242
FWTPYNVVIF
252
LETLKLYDFF
262
PSCDMRKDLR
272

LALSVTETVA
282
FSHCCLNPLI
292
YAFAGEKFRR
302
YLYHLYGK
Residue
Distance (Å)
ILE68
4.759
LEU71
4.094
ASN72
3.471
LEU75
3.599
LEU79
3.809
PHE108
4.584
ILE111
4.105
PHE118
3.626
THR121
4.219
VAL122
3.675
ILE125
4.290
THR142
4.167
VAL147
4.467
THR148
2.960
ILE149
4.118
SER150
3.443
LEU151
3.549
Residue
Distance (Å)
GLY152
3.863
VAL153
3.667
TRP154
3.446
ALA156
4.398
ILE158
3.792
LEU198
3.726
LEU202
3.727
PRO203
3.660
LEU205
3.761
ILE206
3.670
SER208
3.356
TYR209
3.993
TYR211
4.703
PHE212
3.607
ILE215
3.964
PHE219
3.701
LEU234
3.687
References  Top
REF 1 Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv. 2022 Jul;8(26):eabn8048.

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