Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T14853 Target Info
Target Name Fibroblast growth factor-23 (FGF23)
Synonyms Tumor-derived hypophosphatemia-inducing factor; Phosphatonin; HYPF; Fibroblast growth factor 23; FGF-23
Target Type Successful Target
Gene Name FGF23
Biochemical Class Growth factor
UniProt ID
FGF23_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Uridine-5'-Diphosphate Ligand Info
Structure Description Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c PDB:6S22
Method X-ray diffraction Resolution 1.96 Å Mutation No [1]
PDB Sequence
NTPIPRRHTR
179
SA
Residue
Distance (Å)
ARG176
4.692
HIS177
3.112
Residue
Distance (Å)
THR178
2.698
Ligand Name: N-Acetyl-beta-D-galactosamine Ligand Info
Structure Description Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c PDB:6S22
Method X-ray diffraction Resolution 1.96 Å Mutation No [1]
PDB Sequence
NTPIPRRHTR
179
SA
Residue
Distance (Å)
ASN170
4.587
THR171
1.427
PRO172
3.881
Residue
Distance (Å)
ILE173
3.837
PRO174
4.466
References  Top
REF 1 Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3. Nat Chem Biol. 2020 Mar;16(3):351-360.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.