Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14676 | Target Info | |||
| Target Name | A proliferation-inducing ligand (APRIL) | ||||
| Synonyms | ZTNF2; UNQ383/PRO715; Tumor necrosis factor ligand superfamily member 13; TRDL-1; TNF-related death ligand 1; TNF- and APOL-related leukocyte expressed ligand 2; TALL2; TALL-2; CD256 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TNFSF13 | ||||
| Biochemical Class | Cytokine: tumor necrosis factor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Tris-hydroxymethyl-methyl-ammonium | Ligand Info | |||||
| Structure Description | Single-chain human APRIL-BAFF-BAFF Heterotrimer | PDB:4ZCH | ||||
| Method | X-ray diffraction | Resolution | 2.43 Å | Mutation | No | [1] |
| PDB Sequence |
HSVLHLVPIN
16 AASDSDVTEV28 MWQPALRRGR38 GLQAQGYGVR48 IQDAGVYLLY58 SQVLFQDVTF 68 TMGQVVSREG78 QGRQETLFRC88 IRSMPHPDRA99 YNSCYSAGVF109 HLHQGDILSV 119 IIPRARAKLN129 LSPHGTFLGF139 VKLVTQDCLQ156 LIADSETPTI166 QKGSYTFVPW 176 LLSFKRGSAL186 EEKENKILVK196 ETGYFFIYGQ206 VLYTDKTYAM216 GHLIQRKKVH 226 VFGDELSLVT236 LFRCIQNMPE246 TLPNNSCYSA256 GIAKLEEGDE266 LQLAIPRENA 276 QISLDGDVTF286 FGALKLLGVT302 QDCLQLIADS312 ETPTIQKGSY322 TFVPWLLSFK 332 RGSALEEKEN342 KILVKETGYF352 FIYGQVLYTD362 KTYAMGHLIQ372 RKKVHVFGDE 382 LSLVTLFRCI392 QNMPETLPNN402 SCYSAGIAKL412 EEGDELQLAI422 PRENAQISLD 432 GDVTFFGALK442 LL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties. J Biol Chem. 2015 Jun 26;290(26):16330-42. | ||||
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