Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14602 | Target Info | |||
| Target Name | Coagulation factor VIII (F8) | ||||
| Synonyms | Procoagulant component; F8C; Antihemophilic factor; AHF | ||||
| Target Type | Successful Target | ||||
| Gene Name | F8 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2R)-1-(2,4-dichlorophenoxy)-3-[2-imino-3-(2-piperidin-1-ylethyl)benzimidazol-1-yl]propan-2-ol | Ligand Info | |||||
| Structure Description | Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor | PDB:3HNB | ||||
| Method | X-ray diffraction | Resolution | 1.15 Å | Mutation | No | [1] |
| PDB Sequence |
SCSMPLGMES
2182 KAISDAQITA2192 SSYFTNMFAT2202 WSPSKARLHL2212 QGRSNAWRPQ2222 VNNPKEWLQV 2232 DFQKTMKVTG2242 VTTQGVKSLL2252 TSMYVKEFLI2262 SSSQDGHQWT2272 LFFQNGKVKV 2282 FQGNQDSFTP2292 VVNSLDPPLL2302 TRYLRIHPQS2312 WVHQIALRME2322 VLGCEA |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem. 2010 Mar 19;285(12):8824-9. | ||||
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