Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14200 | Target Info | |||
| Target Name | ATP-binding cassette transporter G5 (ABCG5) | ||||
| Synonyms | Sterolin1; ATPbinding cassette subfamily G member 5; ABCG5 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ABCG5 | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | The structure of human ABCG5/ABCG8 purified from mammalian cells | PDB:7R8A | ||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
PHSLGILHAS
44 YSRQILKDVS73 LYVESGQIMC83 ILGSSGSGKT93 TLLDAMSGRG107 TFLGEVYVNG 117 RALRREQFQD127 CFSYVLQSDT137 LLSSLTVRET147 LHYTALLAIR157 RGNPGSFQKK 167 VEAVMAELSL177 SHVADRLIGN187 YSLGGISTGE197 RRRVSIAAQL207 LQDPKVMLFD 217 EPTTGLDCMT227 ANQIVVLLVE237 LARRNRIVVL247 TIHQPRSELF257 QLFDKIAILS 267 FGELIFCGTP277 AEMLDFFNDC287 GYPCPEHSNP297 FDFYMDLTSV307 DTQSKEREIE 317 TSKRVQMIES327 AYKKSAICHK337 TLKNIERMKH347 LKTLPMVPFK357 TKDSPGVFSK 367 LGVLLRRVTR377 NLVRNKLAVI387 TRLLQNLIMG397 LFLLFFVLRV407 RSNVLKGAIQ 417 DRVGLLYQFV427 GATPYTGMLN437 AVNLFPVLRA447 VSDQESQDGL457 YQKWQMMLAY 467 ALHVLPFSVV477 ATMIFSSVCY487 WTLGLHPEVA497 RFGYFSAALL507 APHLIGEFLT 517 LVLLGIVQNP527 NIVNSVVALL537 SIAGVLVGSG547 FLRNIQEMPI557 PFKIISYFTF 567 QKYCSEILVV577 NEFYGLNFTC587 GNPMCAFTQG605 IQFIEKTCPG615 ATSRFTMNFL 625 ILYSFIPALV635 ILGIVVFKIR645 DHLI
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Ergosterol | Ligand Info | |||||
| Structure Description | The structure of human ABCG5/ABCG8 purified from yeast | PDB:7R89 | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
PHSLGILHAS
44 YSRQILKDVS73 LYVESGQIMC83 ILGSSGSGKT93 TLLDAMSGRG107 TFLGEVYVNG 117 RALRREQFQD127 CFSYVLQSDT137 LLSSLTVRET147 LHYTALLAIR157 RGNPGSFQKK 167 VEAVMAELSL177 SHVADRLIGN187 YSLGGISTGE197 RRRVSIAAQL207 LQDPKVMLFD 217 EPTTGLDCMT227 ANQIVVLLVE237 LARRNRIVVL247 TIHQPRSELF257 QLFDKIAILS 267 FGELIFCGTP277 AEMLDFFNDC287 GYPCPEHSNP297 FDFYMDLTSV307 DTQSKEREIE 317 TSKRVQMIES327 AYKKSAICHK337 TLKNIERMKH347 LKTLPMVPFK357 TKDSPGVFSK 367 LGVLLRRVTR377 NLVRNKLAVI387 TRLLQNLIMG397 LFLLFFVLRV407 RSNVLKGAIQ 417 DRVGLLYQFV427 GATPYTGMLN437 AVNLFPVLRA447 VSDQESQDGL457 YQKWQMMLAY 467 ALHVLPFSVV477 ATMIFSSVCY487 WTLGLHPEVA497 RFGYFSAALL507 APHLIGEFLT 517 LVLLGIVQNP527 NIVNSVVALL537 SIAGVLVGSG547 FLRNIQEMPI557 PFKIISYFTF 567 QKYCSEILVV577 NEFYGLNFTC587 GNPMCAFTQG605 IQFIEKTCPG615 ATSRFTMNFL 625 ILYSFIPALV635 ILGIVVFKIR645 DHLI
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| References | Top | ||||
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| REF 1 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2110483118. | ||||
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