Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T13453 Target Info
Target Name Galanin receptor type 2 (GAL2-R)
Synonyms GALR2; GALR-2; GALNR2; GAL2-R
Target Type Literature-reported Target
Gene Name GALR2
Biochemical Class GPCR rhodopsin
UniProt ID
GALR2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Galanin-bound galanin receptor 2 in complex with Gq PDB:7WQ4
Method Electron microscopy Resolution 2.60 Å Mutation No [1]
PDB Sequence
HPEAVIVPLL
31
FALIFLVGTV
41
GNTLVLAVLL
51
RGGQAVSTTN
61
LFILNLGVAD
71

LCFILCCVPF
81
QATIYTLDGW
91
VFGSLLCKAV
101
HFLIFLTMHA
111
SSFTLAAVSL
121

DRYLAIRYPL
131
HSRELRTPRN
141
ALAAIGLIWG
151
LSLLFSGPYL
161
SYYRQSQLAN
171

LTVCHPAWSA
181
PRRRAMDICT
191
FVFSYLLPVL
201
VLGLTYARTL
211
RYLWRAVAGS
225

GARRAKRKVT
235
RMILIVAALF
245
CLCWMPHHAL
255
ILCVWFGQFP
265
LTRATYALRI
275

LSHLVSYANS
285
CVNPIVYALV
295
SKHFRKGFRT
305
IC
Residue
Distance (Å)
TYR196
3.681
LEU197
4.750
LEU201
3.667
LEU205
4.195
ALA208
4.138
LEU211
3.572
Residue
Distance (Å)
ARG212
3.766
TRP215
3.973
THR235
3.876
LEU239
3.908
ALA242
4.609
MET250
3.762
References  Top
REF 1 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. doi:10.1038/s41467-022-29072-3.

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