Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T13348 Target Info
Target Name AP endonuclease 1 (APEX1)
Synonyms Redox factor-1; REF1; REF-1; HAP1; DNA-(apurinic or apyrimidinic site) lyase; Apurinic-apyrimidinic endonuclease 1; APX; APEX nuclease; APEX; APEN; APE1; APE-1; APE
Target Type Clinical trial Target
Gene Name APEX1
Biochemical Class Alpha-carbonic anhydrase
UniProt ID
APEX1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 2-Phosphoglycolic Acid Ligand Info
Structure Description APE1 exonuclease substrate complex with phosphoglycolate PDB:5WN2
Method X-ray diffraction Resolution 2.29 Å Mutation Yes [1]
PDB Sequence
ALYEDPPDQK
52
TSPSGKPATL
62
KICSWNVDGL
72
RAWIKKKGLD
82
WVKEEAPDIL
92

CLQQTKCSEN
102
KLPAELQELP
112
GLSHQYWSAP
122
SDKEGYSGVG
132
LLSRQAPLKV
142

SYGIGDEEHD
152
QEGRVIVAEF
162
DSFVLVTAYV
172
PNAGRGLVRL
182
EYRQRWDEAF
192

RKFLKGLASR
202
KPLVLCGNLN
212
VAHEEIDLRN
222
PKGNKKNAGF
232
TPQERQGFGE
242

LLQAVPLADS
252
FRHLYPNTPY
262
AYTFWTYMMN
272
ARSKNVGWRL
282
DYFLLSHSLL
292

PALCDSKIRS
302
KALGSDHCPI
312
TLYLAL
Residue
Distance (Å)
ASN68
4.092
GLN96
2.890
TYR171
2.646
ASN174
3.149
ASN210
3.300
Residue
Distance (Å)
ASN212
3.061
PHE266
3.511
LEU282
3.228
HIS309
3.012
References  Top
REF 1 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nat Commun. 2018 Jan 26;9(1):399.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.