Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T12084 Target Info
Target Name Retinoblastoma-binding protein 9 (RBBP9)
Synonyms Retinoblastoma-binding protein 10; RBBP10; RBBP-9; RBBP-10; Putative hydrolase RBBP9; Protein BOG; BOG; B5T-overexpressed gene protein
Target Type Literature-reported Target
Gene Name RBBP9
UniProt ID
RBBP9_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-phenylalanine Ligand Info
Structure Description Crystal structure of RBBP9 in complex with phenylalanine PDB:7OEX
Method X-ray diffraction Resolution 1.51 Å Mutation No [1]
PDB Sequence
ASPSKAVIVP
11
GNGGGDVTTH
21
GWYGWVKKEL
31
EKIPGFQCLA
41
KNMPDPITAR
51

ESIWLPFMET
61
ELHCDEKTII
71
IGHSSGAIAA
81
MRYAETHRVY
91
AIVLVSAYTS
101

DLGDENERAS
111
GYFTRPWQWE
121
KIKANCPYIV
131
QFGSTDDPFL
141
PWKEQQEVAD
151

RLETKLHKFT
161
DCGHFQNTEF
171
HELITVVKSL
181
LKVPALEHHH
191
HH
Residue
Distance (Å)
GLY12
3.263
ASN13
2.816
HIS74
4.444
SER75
2.897
SER76
2.895
TYR99
2.880
ASP102
4.836
Residue
Distance (Å)
LEU103
3.762
ASP105
4.026
GLU108
2.774
PHE140
3.569
LEU141
4.021
HIS165
3.583
References  Top
REF 1 Mechanism-based traps enable protease and hydrolase substrate discovery. Nature. 2022 Feb;602(7898):701-707.

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