Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12075 | Target Info | |||
| Target Name | Hedgehog protein (SHH) | ||||
| Synonyms | Sonic hedgehog protein C-product; Sonic hedgehog protein; SHH; HHG-1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SHH | ||||
| Biochemical Class | Hedgehog | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-serine | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Ptch1 and ShhN complex | PDB:6DMY | ||||
| Method | Electron microscopy | Resolution | 3.60 Å | Mutation | No | [1] |
| PDB Sequence |
LTPLAYKQFI
48 PNVAEKTLGA58 SGRYEGKISR68 NSERFKELTP78 NYNPDIIFKD88 EENTGADRLM 98 TQRCKDKLNA108 LAISVMNQWP118 GVKLRVTEGW128 DEDGHHSEES138 LHYEGRAVDI 148 TTSDRDRSKY158 GMLARLAVEA168 GFDWVYYESK178 AHIHCSVKAE188 N |
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex | PDB:6RVD | ||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | No | [2] |
| PDB Sequence |
CGPGRGFGKR
33 RHPKKLTPLA43 YKQFIPNVAE53 KTLGASGRYE63 GKISRNSERF73 KELTPNYNPD 83 IIFKDEENTG93 ADRLMTQRCK103 DKLNALAISV113 MNQWPGVKLR123 VTEGWDEDGH 133 HSEESLHYEG143 RAVDITTSDR153 DRSKYGMLAR163 LAVEAGFDWV173 YYESKAHIHC 183 SVKAENSVAA193 KSGG
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Palmitoyl-CoA | Ligand Info | |||||
| Structure Description | Human HHAT H379C in complex with SHH N-terminal peptide | PDB:7URF | ||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [3] |
| PDB Sequence |
CGPGRGF
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402):eaas8935. | ||||
| REF 2 | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat Chem Biol. 2019 Oct;15(10):975-982. | ||||
| REF 3 | Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature. 2022 Jul;607(7920):816-822. | ||||
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