Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T11808 Target Info
Target Name Kallikrein-5 (KLK5)
Synonyms UNQ570/PRO1132; Stratum corneum tryptic enzyme; SCTE; Kallikrein-like protein 2; KLK-L2
Target Type Patented-recorded Target
Gene Name KLK5
Biochemical Class Peptidase
UniProt ID
KLK5_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide Ligand Info
Structure Description Crystal Structure of Human Kallikrein 5 in complex with GSK144 PDB:6QFE
Method X-ray diffraction Resolution 1.67 Å Mutation No [1]
PDB Sequence
IINGSDCDMH
25
TQPWQAALLL
35
RPNQLYCGAV
45
LVHPQWLLTA
55
AHCRKKVFRV
65

RLGHYSLSPV
75
YESGQQMFQG
85
VKSIPHPGYS
95
HPGHSNDLML
105
IKLNRRIRPT
115

KDVRPINVSS
125
HCPSAGTKCL
137
VSGWGTTKSP
147
QVHFPKVLQC
157
LNISVLSQKR
167

CEDAYPRQID
177
DTMFCAGDKA
186A
GRDSCQGDSG
196
GPVVCNGSLQ
210
GLVSWGDYPC
220

ARPNRPGVYT
229
NLCKFTKWIQ
239
ETIQANS
Residue
Distance (Å)
HIS57
3.256
TYR94
4.705
HIS96
3.433
PRO97
3.726
HIS99
4.469
SER146
4.886
ASP189
2.907
SER190
3.089
CYS191
3.554
GLN192
3.630
SER195
2.867
Residue
Distance (Å)
VAL213
3.590
SER214
2.771
TRP215
3.422
GLY216
3.417
ASP217
3.243
TYR218
3.563
CYS220
3.520
ALA221
4.990
GLY226
3.703
VAL227
4.690
TYR228
4.688
References  Top
REF 1 Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):385-391.

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