Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T11283 Target Info
Target Name Mitochondrial matrix protein P1 (HSPD1)
Synonyms P60 lymphocyte protein; HuCHA60; Hsp60; Heat shock protein 60; HSP-60; Chaperonin 60; CPN60; 60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin
Target Type Clinical trial Target
Gene Name HSPD1
Biochemical Class Chaperonin ATPase
UniProt ID
CH60_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: adenosine diphosphate Ligand Info
Structure Description ADP-bound human mitochondrial Hsp60-Hsp10 football complex PDB:6MRC
Method Electron microscopy Resolution 3.08 Å Mutation No [1]
PDB Sequence
GSAKDVKFGA
10
DARALMLQGV
20
DLLADAVAVT
30
MGPKGRTVII
40
EQSWGSPKVT
50

KDGVTVAKSI
60
DLKDKYKNIG
70
AKLVQDVANN
80
TNEEAGDGTT
90
TATVLARSIA
100

KEGFEKISKG
110
ANPVEIRRGV
120
MLAVDAVIAE
130
LKKQSKPVTT
140
PEEIAQVATI
150

SANGDKEIGN
160
IISDAMKKVG
170
RKGVITVKDG
180
KTLNDELEII
190
EGMKFDRGYI
200

SPYFINTSKG
210
QKCEFQDAYV
220
LLSEKKISSI
230
QSIVPALEIA
240
NAHRKPLVII
250

AEDVDGEALS
260
TLVLNRLKVG
270
LQVVAVKAPG
280
FGDNRKNQLK
290
DMAIATGGAV
300

FGEEGLTLNL
310
EDVQPHDLGK
320
VGEVIVTKDD
330
AMLLKGKGDK
340
AQIEKRIQEI
350

IEQLDVTTSE
360
YEKEKLNERL
370
AKLSDGVAVL
380
KVGGTSDVEV
390
NEKKDRVTDA
400

LNATRAAVEE
410
GIVLGGGCAL
420
LRCIPALDSL
430
TPANEDQKIG
440
IEIIKRTLKI
450

PAMTIAKNAG
460
VEGSLIVEKI
470
MQSSSEVGYD
480
AMAGDFVNMV
490
EKGIIDPTKV
500

VRTALLDAAG
510
VASLLTTAEV
520
VVTEIPKE
Residue
Distance (Å)
THR30
4.018
MET31
2.480
GLY32
1.710
PRO33
2.717
LYS51
3.265
GLY53
4.660
ASP87
2.680
GLY88
2.460
THR89
3.128
THR90
2.429
THR91
3.555
ILE150
2.895
Residue
Distance (Å)
SER151
4.636
GLY415
3.199
GLY416
1.913
GLY417
4.147
ILE455
3.449
TYR479
3.322
ASP480
2.787
ALA481
2.674
MET482
3.615
MET489
4.910
ILE494
2.711
ASP496
2.486
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin. Nat Commun. 2020 Apr 21;11(1):1916.

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