Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T11241 | Target Info | |||
| Target Name | Sphingosine-1-phosphate receptor 3 (S1PR3) | ||||
| Synonyms | Sphingosine 1-phosphate receptor Edg-3; S1PR3; S1P3; S1P receptor Edg-3; S1P receptor 3; Endothelial differentiation G-protein coupled receptor 3 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | S1PR3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Sphingosine-1-phosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | PDB:7EW3 | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
ETLREHYQYV
25 GKLAGRSTLT42 TVLFLVICSF52 IVLENLMVLI62 AIWKNNKFHN72 RMYFFIGNLA 82 LCDLLAGIAY92 KVNILMSGKK102 TFSLSPTVWF112 LREGSMFVAL122 GASTCSLLAI 132 AIERHLTMIK142 MRPYDANKRH152 RVFLLIGMCW162 LIAFTLGALP172 ILGWNCLHNL 182 PDCSTILPLY192 SKKYIAFCIS202 IFTAILVTIV212 ILYARIYFLV222 KSSSRKVANH 232 NNSERSMALL242 RTVVIVVSVF252 IACWSPLFIL262 FLIDVACRVQ272 ACPILFKAQW 282 FIVLAVLNSA292 MNPVIYTLAS302 KEMRRAFFRL312
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TYR22
2.929
LYS27
3.937
ARG31
2.725
ASN95
3.587
SER99
2.733
GLY100
4.954
THR103
3.964
TRP111
4.112
ARG114
3.832
GLU115
2.661
MET118
3.870
PHE119
3.466
LEU122
2.719
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (S)-FTY720P | Ligand Info | |||||
| Structure Description | Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | PDB:7EW2 | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
ETLREHYQYV
25 GKLAGRSTLT42 TVLFLVICSF52 IVLENLMVLI62 AIWKNNKFHN72 RMYFFIGNLA 82 LCDLLAGIAY92 KVNILMSGKK102 TFSLSPTVWF112 LREGSMFVAL122 GASTCSLLAI 132 AIERHLTMIK142 MRPYDANKRH152 RVFLLIGMCW162 LIAFTLGALP172 ILGWNCLHNL 182 PDCSTILPLY192 SKKYIAFCIS202 IFTAILVTIV212 ILYARIYFLV222 KSSSRKVANH 232 NNSERSMALL242 RTVVIVVSVF252 IACWSPLFIL262 FLIDVACRVQ272 ACPILFKAQW 282 FIVLAVLNSA292 MNPVIYTLAS302 KEMRRAFFRL312
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TYR22
3.296
LYS27
4.580
ARG31
2.576
TYR92
4.956
ASN95
2.651
SER99
2.554
GLY100
4.448
THR103
3.411
TRP111
4.427
ARG114
3.730
GLU115
2.818
MET118
3.067
|
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| Ligand Name: N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide | Ligand Info | |||||
| Structure Description | Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | PDB:7EW4 | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
ETLREHYQYV
25 GKLSTLTTVL45 FLVICSFIVL55 ENLMVLIAIW65 KNNKFHNRMY75 FFIGNLALCD 85 LLAGIAYKVN95 ILMSGKKTFS105 LSPTVWFLRE115 GSMFVALGAS125 TCSLLAIAIE 135 RHLTMIKMRP145 YDANKRHRVF155 LLIGMCWLIA165 FTLGALPILG175 WNCLHNLPDC 185 STILPLYSKK195 YIAFCISIFT205 AILVTIVILY215 ARIYFLVKSS225 SRKVANHNNS 235 ERSMALLRTV245 VIVVSVFIAC255 WSPLFILFLI265 DVACRVQACP275 ILFKAQWFIV 285 LAVLNSAMNP295 VIYTLASKEM305 RRAFFRL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JF9 or .JF92 or .JF93 or :3JF9;style chemicals stick;color identity;select .R:118 or .R:119 or .R:122 or .R:123 or .R:126 or .R:168 or .R:189 or .R:200 or .R:201 or .R:203 or .R:204 or .R:207 or .R:256 or .R:259 or .R:260 or .R:263 or .R:284; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res. 2022 Feb;32(2):218-221. | ||||
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