Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10052 | Target Info | |||
| Target Name | G1/S-specific cyclin-E1 (CCNE1) | ||||
| Synonyms | G1/S-specific cyclin E; Cyclin E; CCNE | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CCNE1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Crystal structure of CDK2/cyclin E in complex with PF-06873600 | PDB:7KJS | ||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [1] |
| PDB Sequence |
SPLPANREEV
101 WKIMLNKEKT111 YLRDQHFLEQ121 HPLLQPKMRA131 ILLDWLMEVC141 EVYKLHRETF 151 YLAQDFFDRY161 MATQENVVKT171 LLQLIGISSL181 FIAAKLEEIY191 PPKLHQFAYV 201 TDGACSGDEI211 LTMELMIMKA221 LKWRLSPLTI231 VSWLNVYMQV241 AYLEVLLPQY 255 PQQIFIQIAE265 LLDLCVLDVD275 CLEFPYGILA285 ASALYHFSSS295 ELMQKVSGYQ 305 WCDIENCVKW315 MVPFAMVIRE325 TGSSKLKHFR335 GVADEDAHNI345 QTHRDSLDLL 355 DK
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64(13):9056-9077. | ||||
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