Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T09770 Target Info
Target Name Gastric alcohol dehydrogenase (ADH7)
Synonyms Alcohol dehydrogenase class IV mu/sigma chain; Alcohol dehydrogenase class 4 mu/sigma chain; ADH7
Target Type Literature-reported Target
Gene Name ADH7
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
ADH7_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Nicotinamide-Adenine-Dinucleotide Ligand Info
Structure Description MUTANT OF HUMAN SIGMA ALCOHOL DEHYDROGENASE WITH LEUCINE AT POSITION 141 PDB:1D1T
Method X-ray diffraction Resolution 2.40 Å Mutation Yes [1]
PDB Sequence
GTAGKVIKCK
10
AAVLWEQKQP
20
FSIEEIEVAP
30
PKTKEVRIKI
40
LATGICRTDD
50

HVIKGTMVSK
60
FPVIVGHEAT
70
GIVESIGEGV
80
TTVKPGDKVI
90
PLFLPQCREC
100

NACRNPDGNL
110
CIRSDITGRG
121
VLADGTTRFT
131
CKGKPVHHFL
141
NTSTFTEYTV
151

VDESSVAKID
161
DAAPPEKVCL
171
IGCGFSTGYG
181
AAVKTGKVKP
191
GSTCVVFGLG
201

GVGLSVIMGC
211
KSAGASRIIG
221
IDLNKDKFEK
231
AMAVGATECI
241
SPKDSTKPIS
251

EVLSEMTGNN
261
VGYTFEVIGH
271
LETMIDALAS
281
CHMNYGTSVV
291
VGVPPSAKML
301

TYDPMLLFTG
311
RTWKGCVFGG
321
LKSRDDVPKL
331
VTEFLAKKFD
341
LDQLITHVLP
351

FKKISEGFEL
361
LNSGQSIRTV
371
LTF
Residue
Distance (Å)
CYS46
3.937
ARG47
2.989
THR48
2.700
HIS51
2.774
PHE93
4.432
CYS174
3.412
GLY175
4.763
THR178
3.031
GLY199
3.765
LEU200
3.736
GLY201
3.244
GLY202
3.042
VAL203
2.792
GLY204
4.330
ILE222
4.095
ASP223
2.421
LEU224
3.508
Residue
Distance (Å)
ASN225
4.186
LYS228
3.208
PRO243
4.448
VAL268
3.629
ILE269
3.083
GLY270
3.670
HIS271
3.580
THR274
3.987
VAL292
2.839
GLY293
3.490
VAL294
3.019
CYS317
2.894
VAL318
3.807
PHE319
2.888
GLY320
4.606
LEU362
3.892
ARG369
3.197
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase. Protein Sci. 1999 Dec;8(12):2639-44.

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