Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T09128 Target Info
Target Name Caspase-2 (CASP2)
Synonyms Protease ICH1; Protease ICH-1; Neural precursor cell expressed developmentally downregulated protein 2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD2; NEDD-2; ICH1; Caspase2 subunit p12; CASP-2
Target Type Patented-recorded Target
Gene Name CASP2
Biochemical Class Peptidase
UniProt ID
CASP2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS PDB:6S9K
Method X-ray diffraction Resolution 1.60 Å Mutation No [1]
PDB Sequence
DLLPFPVCES
147
CPLYKKLRLS
157
T
Residue
Distance (Å)
ASP137
3.080
LEU138
1.326
Residue
Distance (Å)
LEU140
1.332
PRO141
3.147
Ligand Name: 1,1,1,3,3,3-Hexafluoro-2-propanol Ligand Info
Structure Description Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS PDB:6S9K
Method X-ray diffraction Resolution 1.60 Å Mutation No [1]
PDB Sequence
DLLPFPVCES
147
CPLYKKLRLS
157
T
Residue
Distance (Å)
PRO143
3.502
CYS145
2.942
SER147
3.273
CYS148
3.297
Residue
Distance (Å)
LYS152
4.312
LEU154
4.266
SER157
3.728
THR158
3.223
References  Top
REF 1 14-3-3 protein binding blocks the dimerization interface of caspase-2. FEBS J. 2020 Aug;287(16):3494-3510.

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