Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T09005 | Target Info | |||
| Target Name | Corynebacterium Mutated CRM197 (Cory mTOX) | ||||
| Synonyms | Diphtheria toxin; DIP0222 | ||||
| Target Type | Successful Target | ||||
| Gene Name | Cory mTOX | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Hydroxyacetone | Ligand Info | |||||
| Structure Description | Crystal structure of diphtheria toxin mutant CRM197 with a disulphide bond replaced by a Cys-Acetone-Cys bridge | PDB:7O4W | ||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | Yes | [1] |
| PDB Sequence |
GADDVVDSSK
10 SFVMENFSSY20 HGTKPGYVDS30 IQKGIQKPKS40 GNYDDDWKEF53 YSTDNKYDAA 63 GYSVDNENPL73 SGKAGGVVKV83 TYPGLTKVLA93 LKVDNAETIK103 KELGLSLTEP 113 LMEQVGTEEF123 IKRFGDGASR133 VVLSLPFAEG143 SSSVEYINNW153 EQAKALSVEL 163 EINFETRGKR173 GQDAMYEYMA183 QACLSCINLD205 WDVIRDKTKT215 KIESLKEHGP 225 IKNKMSESPN235 KTVSEEKAKQ245 YLEEFHQTAL255 EHPELSELKT265 VTGTNPVFAG 275 ANYAAWAVNV285 AQVIDSETAD295 NLEKTTAALS305 ILPGIGSVMG315 IADGAVHHNT 325 EEIVAQSIAL335 SSLMVAQAIP345 LVGELVDIGF355 AAYNFVESII365 NLFQVVHNSY 375 NRPAYSPGHK385 TQPFLHDGYA395 VSWNTVEDSI405 IRTGFQGESG415 HDIKITAENT 425 PLPIAGVLLP435 TIPGKLDVNK445 SKTHISVNGR455 KIRMRCRAID465 GDVTFCRPKS 475 PVYVGNGVHA485 NLHVAFHRSS495 SEKIHSNEIS505 SDSIGVLGYQ515 KTVDHTKVNS 525 KLSLFFEIKS535
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates. Chem Sci. 2022 Feb 10;13(8):2440-2449. | ||||
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