Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T08741 Target Info
Target Name Tyrosine-protein kinase CSK (CSK)
Synonyms Protein-tyrosine kinase CYL; C-Src kinase
Target Type Patented-recorded Target
Gene Name CSK
Biochemical Class Kinase
UniProt ID
CSK_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Staurosporine Ligand Info
Structure Description KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE PDB:1BYG
Method X-ray diffraction Resolution 2.40 Å Mutation No [1]
PDB Sequence
GWALNMKELK
196
LLQTIGKGEF
206
GDVMLGDYRG
216
NKVAVKCIKN
226
DAQAFLAEAS
238

VMTQLRHSNL
248
VQLLGVIVEE
258
GLYIVTEYMA
270
KGSLVDYLRS
280
RGRSVLGGDC
290

LLKFSLDVCE
300
AMEYLEGNNF
310
VHRDLAARNV
320
LVSEDNVAKV
330
SDFGLLPVKW
352

TAPEALREKK
362
FSTKSDVWSF
372
GILLWEIYSF
382
GRVPYPRIPL
392
KDVVPRVEKG
402

YKMDAPDGCP
412
PAVYEVMKNC
422
WHLDAAMRPS
432
FLQLREQLEH
442
IKTHEL
Residue
Distance (Å)
ILE201
3.632
GLY202
3.362
LYS203
3.741
GLY204
4.090
VAL209
3.819
ALA220
3.162
LYS222
4.010
VAL249
3.929
THR266
3.387
GLU267
2.933
Residue
Distance (Å)
TYR268
3.529
MET269
2.663
GLY272
3.660
SER273
3.668
ASP276
4.851
ARG318
3.011
ASN319
3.621
VAL320
4.585
LEU321
3.391
SER331
3.967
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References  Top
REF 1 Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. J Mol Biol. 1999 Jan 15;285(2):713-25.

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