Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T08218 Target Info
Target Name Mycobacterium DTDP-dehydrorhamnose epimerase rmlC (MycB rmlC)
Synonyms dTDP-L-rhamnose synthase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-4-dehydrorhamnose 3,5-epimerase; Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
Target Type Literature-reported Target
Gene Name MycB rmlC
Biochemical Class Racemases and epimerases
UniProt ID
RMLC_MYCTU
Drug Binding Sites of Target  Top
Ligand Name: 2'-Deoxy-thymidine-beta-L-rhamnose Ligand Info
Structure Description RmlC M. tuberculosis with dTDP-rhamnose PDB:2IXC
Method X-ray diffraction Resolution 1.79 Å Mutation No [1]
PDB Sequence
MKARELDVPG
10
AWEITPTIHV
20
DSRGLFFEWL
30
TDHGFRAFAG
40
HSLDVRQVNC
50

SVSSAGVLRG
60
LHFAQLPPSQ
70
AKYVTCVSGS
80
VFDVVVDIRE
90
GSPTFGRWDS
100

VLLDDQDRRT
110
IYVSEGLAHG
120
FLALQDNSTV
130
MYLCSAEYNP
140
QREHTICATD
150

PTLAVDWPLV
160
DGAAPSLSDR
170
DAAAPSFEDV
180
RASGLLPRWE
190
QTQRFIGE
Residue
Distance (Å)
GLN47
3.338
ASN49
3.162
SER51
4.590
ARG59
2.944
GLY60
4.318
HIS62
2.692
GLN70
3.806
LYS72
2.670
HIS119
2.685
Residue
Distance (Å)
GLY120
3.909
PHE121
4.240
TYR132
3.278
TYR138
3.106
GLU143
3.960
SER168
4.342
ARG170
3.453
ASP171
3.864
References  Top
REF 1 RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol. 2007 Jan 5;365(1):146-59.

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