Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T07931 Target Info
Target Name Leukocyte immunoglobulin-like receptor B2 (LILRB2)
Synonyms LIR-2; Leukocyte immunoglobulin-like receptor 2; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; DE AltName: CD_antigen=CD85d
Target Type Clinical trial Target
Gene Name LILRB2
UniProt ID
LIRB2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Benzamidine Ligand Info
Structure Description LilrB2 D1D2 domains complexed with benzamidine PDB:6BCS
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
TIPKPTLWAE
11
PDSVITQGSP
21
VTLSCQGSLE
31
AQEYRLYREK
41
KSASWITRIR
51

PELVKNGQFH
61
IPSITWEHTG
71
RYGCQYYSRA
81
RWSELSDPLV
92
LVMTGAYPKP
102

TLSAQPSPVV
112
TSGGRVTLQC
122
ESQVAFGGFI
132
LCKEGEDEHP
142
QCLNSQPHAR
152

GSSRAIFSVG
162
PVSPNRRWSH
172
RCYGYDLNSP
182
YVWSSPSDLL
192
ELLVPG
Residue
Distance (Å)
ASP13
2.524
SER14
3.352
VAL15
3.454
TYR38
3.990
ARG39
4.360
GLU40
3.190
ILE47
4.093
ARG72
3.363
TYR73
3.392
GLY74
3.402
LEU87
4.022
PRO90
4.243
TYR99
3.273
PRO100
3.477
Residue
Distance (Å)
VAL126
3.538
ALA127
2.888
PHE128
3.460
ILE132
3.511
CYS134
3.706
PRO142
3.699
CYS144
3.421
ASN146
2.750
TYR175
4.876
TYR177
3.554
ASP178
2.615
PRO182
3.203
TYR183
4.315
TRP185
3.752
References  Top
REF 1 Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 Dec;10(12):1213-1221.

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