Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T06770 Target Info
Target Name Human immunodeficiency virus Glycoprotein 41 (HIV gp41)
Synonyms Env polyprotein gp41 (33-511)
Target Type Successful Target
Gene Name HIV gp41
UniProt ID
ENV_HV1H2
Drug Binding Sites of Target  Top
Ligand Name: [(1~{R})-1-azanyl-3-phenyl-propyl]-[(2~{S})-2-methanoyl-4-methyl-pentyl]phosphinic acid Ligand Info
Structure Description High-resolution crystal structure of ERAP1 in complex with 15mer phosphinic peptide PDB:6RYF
Method X-ray diffraction Resolution 1.72 Å Mutation No [1]
PDB Sequence
RIQRAFVTI
Residue
Distance (Å)
ARG2
1.318
Residue
Distance (Å)
ILE3
3.841
References  Top
REF 1 Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26709-26716.

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