Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06020 | Target Info | |||
| Target Name | Neonatal Fc receptor (FCGRT) | ||||
| Synonyms | Neonatal FcR; MHC class I family-like Fc receptor; IgG Fc fragment receptor transporter, alpha chain; FcRn; FCGRT | ||||
| Target Type | Successful Target | ||||
| Gene Name | FCGRT | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1-[7-(3-Fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]ethanone | Ligand Info | |||||
| Structure Description | Crystal structure of FcRn bound to UCB-84 | PDB:6C98 | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [1] |
| PDB Sequence |
HLSLLYHLTA
13 VSSPAPGTPA23 FWVSGWLGPQ33 QYLSYNSLRG43 EAEPCGAWVW53 ENQVSWYWEK 63 ETTDLRIKEK73 LFLEAFKALG83 GPYTLQGLLG95 CELGPDNTSV105 PTAKFALNGE 115 EFMNFDLKQG125 TWGGDWPEAL135 AISQRWQQQD145 KAANKELTFL155 LFSCPHRLRE 165 HLERGRGNLE175 WKEPPSMRLK185 ARPSSPGFSV195 LTCSAFSFYP205 PELQLRFLRN 215 GLAAGTGQGD225 FGPNSDGSFH235 ASSSLTVKSG245 DEHHYCCIVQ255 HAGLAQPLRV 265 EL
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| Ligand Name: Methyl 7-(3,5-difluorophenyl)-5-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate | Ligand Info | |||||
| Structure Description | Crystal structure of FcRn bound to UCB-303 | PDB:6C99 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
HLSLLYHLTA
13 VSSPAPGTPA23 FWVSGWLGPQ33 QYLSYNSLRG43 EAEPCGAWVW53 ENQVSWYWEK 63 ETTDLRIKEK73 LFLEAFKALG83 GKGPYTLQGL93 LGCELGPDNT103 SVPTAKFALN 113 GEEFMNFDLK123 QGTWGGDWPE133 ALAISQRWQQ143 QDKAANKELT153 FLLFSCPHRL 163 REHLERGRGN173 LEWKEPPSMR183 LKARPSSPGF193 SVLTCSAFSF203 YPPELQLRFL 213 RNGLAAGTGQ223 GDFGPNSDGS233 FHASSSLTVK243 SGDEHHYCCI253 VQHAGLAQPL 263 RVELE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biol. 2018 May 21;16(5):e2006192. | ||||
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