Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05806 | Target Info | |||
| Target Name | Valacyclovir hydrolase (BPHL) | ||||
| Synonyms | VACVase; MCNAA; DJ40E16.6.1; Breast epithelial mucin-associated antigen; Bph-rp; Biphenyl hydrolase-like protein (Serine hydrolase) (Breast epithelial mucin-associated antigen, MCNAA, Bph-rp), variant 1; Biphenyl hydrolase-like protein; BPHL | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BPHL | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-tyrosinamide | Ligand Info | |||||
| Structure Description | Crystal structure of valacyclovir hydrolase complexed with a product analogue | PDB:2OCI | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
SVTSAKVAVN
30 GVQLHYQQTG40 EGDHAVLLLP50 GMLGSGETDF60 GPQLKNLNKK70 LFTVVAWDPR 80 GYGHSRPPDR90 DFPADFFERD100 AKDAVDLMKA110 LKFKKVSLLG120 WSDGGITALI 130 AAAKYPSYIH140 KMVIWGANAY150 VTDEDSMIYE160 GIRDVSKWSE170 RTRKPLEALY 180 GYDYFARTCE190 KWVDGIRQFK200 HLPDGNICRH210 LLPRVQCPAL220 IVHGEKDPLV 230 PRFHADFIHK240 HVKGSRLHLM250 PEGKHNLHLR260 FADEFNKLAE270 DFLQ |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. J Biol Chem. 2008 Apr 4;283(14):9318-27. | ||||
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