Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T05249 Target Info
Target Name Zinc alpha-2 glycoprotein (AZGP1)
Synonyms Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; Zinc-alpha-2-glycoprotein; ZNGP1; ZAG
Target Type Literature-reported Target
Gene Name AZGP1
UniProt ID
ZA2G_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 11-(Dansylamino)undecanoic acid Ligand Info
Structure Description Zinc-alpha2-Glycoprotein with a Fluorescent Dansyl C 11 Fatty Acid PDB:6R2U
Method X-ray diffraction Resolution 2.49 Å Mutation No [1]
PDB Sequence
DGRYSLTYIY
14
TGLSKHVEDV
24
PAFQALGSLN
34
DLQFFRYNSK
44
DRKSQPMGLW
54

RQVEGMEDWK
64
QDSQLQKARE
74
DIFMETLKDI
84
VEYYNDSNGS
94
HVLQGRFGCE
104

IENNRSSGAF
114
WKYYYDGKDY
124
IEFNKEIPAW
134
VPFDPAAQIT
144
KQKWEAEPVY
154

VQRAKAYLEE
164
ECPATLRKYL
174
KYSKNILDRQ
184
DPPSVVVTSH
194
QAPGEKKKLK
204

CLAYDFYPGK
214
IDVHWTRAGE
224
VQEPELRGDV
234
LHNGNGTYQS
244
WVVVAVPPQD
254

TAPYSCHVQH
264
SSLAQPLVVP
274
WE
Residue
Distance (Å)
VAL190
3.736
THR192
3.801
LYS204
3.003
LEU206
3.624
Residue
Distance (Å)
TYR208
3.843
VAL234
3.601
GLN243
3.053
TRP245
3.785
References  Top
REF 1 Crystal structure of zinc-Alpha2-glycoprotein in complex with a fatty acid reveals multiple different modes of protein-lipid binding. Biochem J. 2019 Oct 15;476(19):2815-2834.

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