Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T05090 | Target Info | |||
Target Name | Histone deacetylase 3 (HDAC3) | ||||
Synonyms | SMAP45; RPD32; RPD3-2; HD3 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | HDAC3 | ||||
Biochemical Class | Carbon-nitrogen hydrolase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: 1D-myo-Inositol 1,4,5,6-tetrakisphosphate | Ligand Info | |||||
Structure Description | Structure of HDAC3 bound to corepressor and inositol tetraphosphate | PDB:4A69 | ||||
Method | X-ray diffraction | Resolution | 2.06 Å | Mutation | No | [1] |
PDB Sequence |
AKTVAYFYDP
11 DVGNFHYGAG21 HPMKPHRLAL31 THSLVLHYGL41 YKKMIVFKPY51 QASQHDMCRF 61 HSEDYIDFLQ71 RVSPTNMQGF81 TKSLNAFNVG91 DDCPVFPGLF101 EFCSRYTGAS 111 LQGATQLNNK121 ICDIAINWAG131 GLHHAKKFEA141 SGFCYVNDIV151 IGILELLKYH 161 PRVLYIDIDI171 HHGDGVQEAF181 YLTDRVMTVS191 FHKYGNYFFP201 GTGDMYEVGA 211 ESGRYYCLNV221 PLRDGIDDQS231 YKHLFQPVIN241 QVVDFYQPTC251 IVLQCGADSL 261 GCDRLGCFNL271 SIRGHGECVE281 YVKSFNIPLL291 VLGGGGYTVR301 NVARCWTYET 311 SLLVEEAISE321 ELPYSEYFEY331 FAPDFTLHPD341 VSTRIENQNS351 RQYLDQIRQT 361 IFENLKMLN
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References | Top | ||||
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REF 1 | Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature. 2012 Jan 9;481(7381):335-40. |
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