Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T04361 Target Info
Target Name TGF-beta-activated kinase 1 (MAP3K7)
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Target Type Literature-reported Target
Gene Name MAP3K7
Biochemical Class Kinase
UniProt ID
M3K7_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenosine Ligand Info
Structure Description Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1 PDB:2EVA
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
SLHMIDYKEI
36
EVEEVVGRGA
46
FGVVCKAKWR
56
AKDVAIKQIE
66
SESERKAFIV
76

ELRQLSRVNH
86
PNIVKLYGAC
96
LNPVCLVMEY
106
AEGGSLYNVL
116
HGAEPLPYYT
126

AAHAMSWCLQ
136
CSQGVAYLHS
146
MQPKALIHRD
156
LKPPNLLLVA
166
GGTVLKICDF
176

GTGSAAWMAP
198
EVFEGSNYSE
208
KCDVFSWGII
218
LWEVITRRKP
228
FDEIGGPAFR
238

IMWAVHNGTR
248
PPLIKNLPKP
258
IESLMTRCWS
268
KDPSQRPSME
278
EIVKIMTHLM
288

RYFPGADEPL
298
QYPCQHSLPP
472
GEDGRVEPYV
482
DFAEFYRLWS
492
VDHGE
Residue
Distance (Å)
VAL42
3.864
GLY43
3.896
ARG44
3.345
GLY45
3.408
VAL50
3.729
ALA61
3.564
VAL90
4.778
MET104
3.869
GLU105
2.536
Residue
Distance (Å)
TYR106
3.588
ALA107
2.732
GLY110
4.718
SER111
3.423
PRO160
3.693
ASN161
4.753
LEU163
3.530
CYS174
4.410
ASP175
3.125
References  Top
REF 1 Structural basis for the interaction of TAK1 kinase with its activating protein TAB1. J Mol Biol. 2005 Dec 16;354(5):1013-20.

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