Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T03581 Target Info
Target Name NDR1 protein kinase (STK38)
Synonyms Serine/threonine-protein kinase 38; Nuclear Dbf2-related kinase 1; NDR1
Target Type Literature-reported Target
Gene Name STK38
Biochemical Class Kinase
UniProt ID
STK38_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: AMP-PNP Ligand Info
Structure Description X-ray crystal structure of NDR1 kinase domain PDB:6BXI
Method X-ray diffraction Resolution 2.20 Å Mutation No [1]
PDB Sequence
TRLGLEDFES
91
LKVIGRGAFG
101
EVRLVQKKDT
111
GHVYAMKILR
121
KADMLEKEQV
131

GHIRAERDIL
141
VEADSLWVVK
151
MFYSFQDKLN
161
LYLIMEFLPG
171
GDMMTLLMKK
181

DTLTEEETQF
191
YIAETVLAID
201
SIHQLGFIHR
211
DIKPDNLLLD
221
SKGHVKLSDF
231

GLCTGLKKAH
241
RTEFYRNLNH
251
SLPSDFTFQN
261
MNSKRKAETW
271
KRNRRQLAFS
281

TVGTPDYIAP
291
EVFMQTGYNK
301
LCDWWSLGVI
311
MYEMLIGYPP
321
FCSETPQETY
331

KKVMNWKETL
341
TFPPEVPISE
351
KAKDLILRFC
361
CEWEHRIGAP
371
GVEEIKSNSF
381

FEGVDWEHIR
391
ERPAAISIEI
401
KSIDDTSNFD
411
EFP
Residue
Distance (Å)
ILE95
3.752
GLY96
3.620
ARG97
4.416
GLY98
3.148
ALA99
4.314
PHE100
4.650
GLY101
4.606
VAL103
3.367
ALA116
3.684
LYS118
3.055
LEU120
4.349
VAL150
3.667
MET166
3.528
GLU167
2.907
Residue
Distance (Å)
PHE168
3.770
LEU169
2.956
ASP173
2.582
ASP212
3.954
ASP216
2.501
ASN217
2.944
LEU219
3.585
SER229
3.598
ASP230
3.522
PHE231
4.202
GLY232
4.764
CYS234
3.262
PHE410
3.060
References  Top
REF 1 Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure. 2018 Aug 7;26(8):1101-1115.e6.

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