Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T03410 Target Info
Target Name Mycobacterium Membrane protein mmpL3 (MycB mmpL3)
Synonyms Trehalose monomycolate exporter MmpL3; TMM exporter MmpL3
Target Type Clinical trial Target
Gene Name MycB mmpL3
UniProt ID
MMPL3_MYCTU
Drug Binding Sites of Target  Top
Ligand Name: Lauryl Maltose Neopentyl Glycol Ligand Info
Structure Description Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis PDB:7NVH
Method Electron microscopy Resolution 3.00 Å Mutation No [1]
PDB Sequence
MFAWWGRTVY
10
RYRFIVIGVM
20
VALCLGGGVF
30
GLSLGKHVTQ
40
SGFYDDGSQS
50

VQASVLGDQV
60
YGRDRSGHIV
70
AIFQAPAGKT
80
VDDPAWSKKV
90
VDELNRFQQD
100

HPDQVLGWAG
110
YLRASQATGM
120
ATADKKYTFV
130
SIPLKGDDDD
140
TILNNYKAIA
150

PDLQRLDGGT
160
VKLAGLQPVA
170
EALTGTIATD
180
QRRMEVLALP
190
LVAVVLFFVF
200

GGVIAAGLPV
210
MVGGLCIAGA
220
LGIMRFLAIF
230
GPVHYFAQPV
240
VSLIGLGIAI
250

DYGLFIVSRF
260
REEIAEGYDT
270
ETAVRRTVIT
280
AGRTVTFSAV
290
LIVASAIGLL
300

LFPQGFLKSL
310
TYATIASVML
320
SAILSITVLP
330
ACLGILGKHV
340
DAEEVEAGFW
385

GKLVNRVMKR
395
PVLFAAPIVI
405
IMILLIIPVG
415
KLSLGGISEK
425
YLPPTNSVRQ
435

AQEEFDKLFP
445
GYRTNPLTLV
455
IQTSNHQPVT
465
DAQIADIRSK
475
AMAIGGFIEP
485

DNDPANMWQE
495
RAYAVGASKD
505
PSVRVLQNGL
515
INPADASKKL
525
TELRAITPPK
535

GITVLVGGTP
545
ALELDSIHGL
555
FAKMPLMVVI
565
LLTTTIVLMF
575
LAFGSVVLPI
585

KATLMSALTL
595
GSTMGILTWI
605
FVDGHFSKWL
615
NFTPTPLTAP
625
VIGLIIALVF
635

GLSTDYEVFL
645
VSRMVEARER
655
GMSTQEAIRI
665
GTAATGRIIT
675
AAALIVAVVA
685

GAFVFSDLVM
695
MKYLAFGLMA
705
ALLLDATVVR
715
MFLVPSVMKL
725
LGDDCWWAPR
735

WARRLQTRIG
745
LGEIHLP
Residue
Distance (Å)
GLN40
3.591
SER41
3.530
GLY42
4.298
PHE43
4.718
TYR44
3.646
ASP46
4.082
VAL51
3.692
SER54
3.207
VAL55
3.962
ASP58
3.477
GLY67
3.753
VAL70
4.407
ASP139
3.345
GLY165
3.655
LEU166
3.657
VAL169
3.562
ALA170
4.681
LEU173
3.700
THR174
3.650
Residue
Distance (Å)
ILE177
3.653
HIS234
3.579
TYR235
3.604
PHE236
3.495
GLY421
3.985
ILE422
2.876
SER423
4.098
GLU424
4.070
GLN437
3.311
PHE440
4.049
TYR447
3.838
ARG448
2.938
THR449
4.806
ASN450
3.103
PRO518
3.859
THR544
4.110
LEU547
3.810
GLU548
3.169
LEU693
4.032
References  Top
REF 1 Cryo-EM structure and resistance landscape of M.?tuberculosis MmpL3: An emergent therapeutic target. Structure. 2021 Oct 7;29(10):1182-1191.e4.

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