Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T02591 Target Info
Target Name Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env)
Synonyms Envelope glycoprotein gp160; Env polyprotein
Target Type Clinical trial Target
Gene Name HIV env
UniProt ID
ENV_HV1H2
Drug Binding Sites of Target  Top
Ligand Name: Pentane-1,5-diamine Ligand Info
Structure Description Crystal structure of C14linkmid/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the gp41 hydrophobic pocket PDB:1GZL
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [1]
PDB Sequence
WEEWDREIEN
637
YT
Residue
Distance (Å)
GLU629
1.334
GLU630
4.981
ASP632
2.821
Residue
Distance (Å)
ARG633
3.611
GLU636
1.329
References  Top
REF 1 Short constrained peptides that inhibit HIV-1 entry. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14664-9.

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