Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T02226 Target Info
Target Name HUMAN calcitonin gene-related peptide type 1 receptor (CALCRL)
Synonyms Calcitonin receptor-like receptor; Calcitonin gene-related peptide type 1 receptor; CGRPR; CGRP type 1 receptor
Gene Name CALCRL
Biochemical Class GPCR secretin
UniProt ID
CALRL_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Olcegepant Ligand Info
Structure Description Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism PDB:3N7S
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
IQLGVTRNKI
41
MTAQYECYQK
51
IMQDPIEGVY
64
CNRTWDGWLC
74
WNDVAAGTES
84

MQLCPDYFQD
94
FDPSEKVTKI
104
CDQDGNWFRH
114
PASNRTWTNY
124
TQCN
Residue
Distance (Å)
ARG38
4.041
ILE41
3.759
MET42
3.832
ASP70
3.481
GLY71
3.300
TRP72
2.832
PHE92
3.643
ASP94
2.681
PHE95
3.816
Residue
Distance (Å)
ARG119
3.154
THR120
4.395
TRP121
3.268
THR122
2.764
ASN123
4.810
TYR124
3.672
THR125
4.079
ASN128
4.775
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010 Sep 8;18(9):1083-93.

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