Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T01908 Target Info
Target Name Tissue kallikrein (KLK2)
Synonyms hGK-1; Tissue kallikrein-2; Kallikrein-2; Glandular kallikrein-1
Target Type Clinical trial Target
Gene Name KLK2
Biochemical Class Peptidase
UniProt ID
KLK2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Benzamidine Ligand Info
Structure Description Human kallikrein-related peptidase 2 in complex with benzamidine PDB:4NFE
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
IVGGWECEKH
25
SQPWQVAVYS
35
HGWAHCGGVL
46
VHPQWVLTAA
56
HCLKKNSQVW
67

LGRHNLFEPE
77
DTGQRVPVSH
87
SFPHPLYNMS
95B
LDSSHDLMLL
106
RLSEPAKITD
116

VVKVLGLPTQ
128
EPALGTTCYA
138
SGWGSIEPEE
148
FLRPRSLQCV
158
SLHLLSNDMC
168

ARAYSEKVTE
178
FMLCAGLWTG
186B
GKDTCGGDSG
196
GPLVCNGVLQ
210
GITSWGPEPC
220

ALPEKPAVYT
229
KVVHYRKWIK
239
DTIAANP
Residue
Distance (Å)
TRP20
2.934
GLU21
4.169
CYS22
3.583
GLU23
2.956
SER26
3.723
GLN27
3.790
TYR137
2.542
CYS157
4.376
ASP189
2.812
THR190
2.815
CYS191
3.896
GLY192
3.677
Residue
Distance (Å)
SER195
3.309
THR213
4.029
SER214
3.920
TRP215
3.704
GLY216
3.416
PRO217
3.027
GLU218
3.635
CYS220
3.653
ALA221
4.818
ALA226
3.122
TYR228
4.676
References  Top
REF 1 Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. J Biol Chem. 2014 Dec 5;289(49):34267-83.

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