Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01478 | Target Info | |||
| Target Name | HUMAN centrosomal protein 250 (Cep250) | ||||
| Synonyms | C-Nap1; Centrosome-associated protein CEP250; Centrosomal protein 2; Centrosomal Nek2-associated protein 1; 250 kDa centrosomal protein | ||||
| Gene Name | CEP250 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione | Ligand Info | |||||
| Structure Description | Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product | PDB:6OQA | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
PRLQRELERL
2155 QAALRQTEAR2165 EIEWREKAQD2175 LALSLAQTKA2185 SVSSLQEVAM2195 FLQASVLERD 2205 SEQQRLQDEL2215 ELTRRALEKE2225 RLH
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17195-17203. | ||||
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