Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01282 | Target Info | |||
| Target Name | Transmembrane protease serine 2 (TMPRSS2) | ||||
| Synonyms | TMPRSS2 protease; TMPRSS2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TMPRSS2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 4-Guanidinobenzoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human TMPRSS2 in complex with Nafamostat | PDB:7MEQ | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [1] |
| PDB Sequence |
CVRLYGPNFI
157 LQVYSSSWHP170 VCQDDWNENY180 GRAACRDMGY190 KNNFYSSQGI200 VDSFMKLNTS 215 AIYKKLYHSD229 ACSSKAVVSL239 RCIACGVNLN249 IVGGESALPG265 AWPWQVSLHV 275 QNVHVCGGSI285 ITPEWIVTAA295 HCVEKPLNNP305 WHWTAFAGIL315 RQSFMFYGAG 325 YQVEKVISHP335 NYDSKTKNND345 IALMKLQKPL355 TFNDLVKPVC365 LPNPGMMLQP 375 EQLCWISGWG385 ATEEKGKTSE395 VLNAAKVLLI405 ETQRCNSRYV415 YDNLITPAMI 425 CAGFLQGNVD435 SCQGDSGGPL445 VTSKNNIWWL455 IGDTSWGSGC465 AKAYRPGVYG 475 NVMVFTDWIY485 RQMRAD
|
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HIS296
4.423
TYR416
4.471
ASP435
2.762
SER436
2.790
CYS437
3.391
GLN438
3.499
GLY439
3.372
ASP440
3.855
SER441
1.468
THR459
3.689
SER460
4.034
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Nat Chem Biol. 2022 Sep;18(9):963-971. | ||||
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