Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T01249 Target Info
Target Name HUMAN dCTP pyrophosphatase 1
Synonyms XTP3-transactivated gene A protein ; RS21C6 ; Deoxycytidine-triphosphatase 1; dCTPase 1
Gene Name DCTPP1
UniProt ID
DCTP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Triptolide Ligand Info
Structure Description Human DCTPP1 bound to Triptolide PDB:7MU5
Method X-ray diffraction Resolution 2.20 Å Mutation No [1]
PDB Sequence
GRFSFSPEPT
30
LEDIRRLHAE
40
FAAERDWEQF
50
HQPRNLLLAL
60
VGEVGELAEL
70

FQWKTDGEPG
80
PQGWSPRERA
90
ALQEELSDVL
100
IYLVALAARC
110
RVDLPLAVLS
120

KMDINRRRYP
130
Residue
Distance (Å)
HIS38
4.444
PHE41
3.906
TRP47
2.689
PHE50
2.458
HIS51
2.448
Residue
Distance (Å)
GLN72
4.950
TRP73
2.512
LYS74
4.935
GLU88
4.892
TYR102
2.882
References  Top
REF 1 Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance

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