Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00938 | Target Info | |||
| Target Name | Melanoma antigen gp75 (TYRP1) | ||||
| Synonyms | Tyrosinaserelated protein 1; TYRP1; TRP; Glycoprotein 75; Catalase B; 5,6dihydroxyindole2carboxylic acid oxidase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TYRP1 | ||||
| Biochemical Class | Tyrosinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-tyrosine | Ligand Info | |||||
| Structure Description | Crystal structure of human tyrosinase related protein 1 in complex with tyrosine | PDB:5M8P | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGYSD364 PTGKYDPAVR374 SLHNLAHLFL 384 NGTGGQTHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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| Ligand Name: Phenylthiourea | Ligand Info | |||||
| Structure Description | Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with phenylthiourea (PTU) | PDB:5M8S | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [2] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGFSD364 PTGKYDPAVS374 SLHNLAHLFL 384 NGTGGQVHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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| Ligand Name: Tropolone | Ligand Info | |||||
| Structure Description | Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone | PDB:5M8T | ||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | Yes | [1] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGFSD364 PTGKYDPAVS374 SLHNLAHLFL 384 NGTGGQVHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0TR or .0TR2 or .0TR3 or :30TR;style chemicals stick;color identity;select .A:192 or .A:215 or .A:220 or .A:377 or .A:378 or .A:381 or .A:382 or .A:388 or .A:389 or .A:390 or .A:391 or .A:394 or .A:400; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Kojic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human tyrosinase related protein 1 in complex with kojic acid | PDB:5M8M | ||||
| Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [1] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGYSD364 PTGKYDPAVR374 SLHNLAHLFL 384 NGTGGQTHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .KOJ or .KOJ2 or .KOJ3 or :3KOJ;style chemicals stick;color identity;select .A:192 or .A:215 or .A:362 or .A:374 or .A:377 or .A:378 or .A:381 or .A:382 or .A:388 or .A:389 or .A:390 or .A:391 or .A:394 or .A:400; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: L-mimosine | Ligand Info | |||||
| Structure Description | Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with mimosine | PDB:5M8R | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGFSD364 PTGKYDPAVS374 SLHNLAHLFL 384 NGTGGQVHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MMS or .MMS2 or .MMS3 or :3MMS;style chemicals stick;color identity;select .A:192 or .A:215 or .A:220 or .A:362 or .A:374 or .A:377 or .A:378 or .A:381 or .A:382 or .A:388 or .A:389 or .A:390 or .A:391 or .A:394 or .A:400; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of Human Tyrosinase Related Protein?1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9812-9815. | ||||
| REF 2 | Phenylthiourea Binding to Human Tyrosinase-Related Protein 1. doi:10.3390/ijms21030915. | ||||
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